Seroatlas · Human Serome Atlas

OR51E2

Olfactory receptor 51E2

Also known as: O51E2_HUMAN, PSGR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H255
Gene: OR51E2
Ensembl: ENSG00000167332
Chromosome: 11
Canonical length: 320 aa
Protein class: Cancer-related genes, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>Q9H255|OR51E2
     1  MSSCNFTHAT FVLIGIPGLE KAHFWVGFPL LSMYVVAMFG NCIVVFIVRT ERSLHAPMYL
    61  FLCMLAAIDL ALSTSTMPKI LALFWFDSRE ISFEACLTQM FFIHALSAIE STILLAMAFD
   121  RYVAICHPLR HAAVLNNTVT AQIGIVAVVR GSLFFFPLPL LIKRLAFCHS NVLSHSYCVH
   181  QDVMKLAYAD TLPNVVYGLT AILLVMGVDV MFISLSYFLI IRTVLQLPSK SERAKAFGTC
   241  VSHIGVVLAF YVPLIGLSVV HRFGNSLHPI VRVVMGDIYL LLPPVINPII YGAKTKQIRT
   301  RVLAMFKISC DKDLQAVGGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51E2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

prostate: 27 nTPM
blood vessel: 10 nTPM
colon: 9.2 nTPM
placenta: 3.7 nTPM
seminal vesicle: 2.2 nTPM
rectum: 2 nTPM

Single-cell type

prostatic glandular cells: 148 nCPM
neuroendocrine cells: 51 nCPM
retinal pigment epithelial cells: 43 nCPM
vascular smooth muscle cells: 9.9 nCPM
basal prostatic cells: 2.7 nCPM
pericytes: 0.9 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 2.7 nTPM
choroid plexus: 2.5 nTPM
thalamus: 2.4 nTPM
cerebral cortex: 2.3 nTPM
cerebellum: 2.2 nTPM
hippocampal formation: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -1.5
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51E2 as an antibody target. Whether an autoantibody or antibody against OR51E2 could matter depends on whether native OR51E2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51E2 is annotated at the cell surface, where native OR51E2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51E2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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