Seroatlas · Human Serome Atlas

OR51E1

Olfactory receptor 51E1

Also known as: GPR136, GPR164, O51E1_HUMAN, OR51E1P, OR52A3P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TCB6
Gene
OR51E1
Ensembl
ENSG00000180785
Chromosome
11
Canonical length
318 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q8TCB6|OR51E1
     1  MMVDPNGNES SATYFILIGL PGLEEAQFWL AFPLCSLYLI AVLGNLTIIY IVRTEHSLHE
    61  PMYIFLCMLS GIDILISTSS MPKMLAIFWF NSTTIQFDAC LLQMFAIHSL SGMESTVLLA
   121  MAFDRYVAIC HPLRHATVLT LPRVTKIGVA AVVRGAALMA PLPVFIKQLP FCRSNILSHS
   181  YCLHQDVMKL ACDDIRVNVV YGLIVIISAI GLDSLLISFS YLLILKTVLG LTREAQAKAF
   241  GTCVSHVCAV FIFYVPFIGL SMVHRFSKRR DSPLPVILAN IYLLVPPVLN PIVYGVKTKE
   301  IRQRILRLFH VATHASEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
7 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 7 nTPM
  • prostate: 6.2 nTPM
  • adipose tissue: 5.4 nTPM
  • heart muscle: 3.7 nTPM
  • tongue: 3.7 nTPM
  • blood vessel: 3.1 nTPM

Single-cell type

  • prostatic glandular cells: 130 nCPM
  • neuroendocrine cells: 49 nCPM
  • vascular smooth muscle cells: 27 nCPM
  • pericytes: 7.6 nCPM
  • oocytes: 4.6 nCPM
  • vascular endothelial cells: 4.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • pons: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OR51E1.

Disease | ImmuneIEDB

Conditions an epitope on OR51E1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.68
gnomAD pLI
0
gnomAD missense Z
0.24
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51E1 as an antibody target. Whether an autoantibody or antibody against OR51E1 could matter depends on whether native OR51E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51E1 is annotated at the cell surface, where native OR51E1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OR51E1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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