Seroatlas · Human Serome Atlas

OR51D1

Olfactory receptor 51D1

Also known as: O51D1_HUMAN, OR51D1Q

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGF3
Gene: OR51D1
Ensembl: ENSG00000197428
Chromosome: 11
Canonical length: 324 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q8NGF3|OR51D1
     1  MQKPQLLVPI IATSNGNLVH AAYFLLVGIP GLGPTIHFWL AFPLCFMYAL ATLGNLTIVL
    61  IIRVERRLHE PMYLFLAMLS TIDLVLSSIT MPKMASLFLM GIQEIEFNIC LAQMFLIHAL
   121  SAVESAVLLA MAFDRFVAIC HPLRHASVLT GCTVAKIGLS ALTRGFVFFF PLPFILKWLS
   181  YCQTHTVTHS FCLHQDIMKL SCTDTRVNVV YGLFIILSVM GVDSLFIGFS YILILWAVLE
   241  LSSRRAALKA FNTCISHLCA VLVFYVPLIG LSVVHRLGGP TSLLHVVMAN TYLLLPPVVN
   301  PLVYGAKTKE ICSRVLCMFS QGGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0.1 nTPM
choroid plexus: 0.1 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

prostatic glandular cells: 1.2 nCPM
gastric chief cells: 1.1 nCPM
foveolar cells: 0.6 nCPM
neuroendocrine cells: 0.5 nCPM
early primary spermatocytes: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 1.6 nTPM
cerebral cortex: 1.3 nTPM
basal ganglia: 1.1 nTPM
medulla oblongata: 1.1 nTPM
pons: 1.1 nTPM
amygdala: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -1.19
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to lipid

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51D1 as an antibody target. Whether an autoantibody or antibody against OR51D1 could matter depends on whether native OR51D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51D1 is annotated at the cell surface, where native OR51D1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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