Seroatlas · Human Serome Atlas

OR51B4

Olfactory receptor 51B4

Also known as: O51B4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5P0
Gene: OR51B4
Ensembl: ENSG00000183251
Chromosome: 11
Canonical length: 310 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q9Y5P0|OR51B4
     1  MWYNNSAGPF LLTGFLGSEA VHYRISMSFF VIYFSVLFGN GTLLVLIWND HSLHEPMYYF
    61  LAMLADTDLG MTFTTMPTVL GVLLLDQREI AHAACFTQSF IHSLAIVESG ILLVLAYDCF
   121  IAIRTPLRYN CILTNSRVMN IGLGVLMRGF MSILPIILSL YCYPYCGSRA LLHTFCLHQD
   181  VIKLACADIT FNHIYPIIQT SLTVFLDALI IIFSYILILK TVMGIASGQE EAKSLNTCVS
   241  HISCVLVFHI TVMGLSFIHR FGKHAPHVVP ITMSYVHFLF PPFVNPIIYS IKTKQIQRSI
   301  IRLFSGQSRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51B4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

ovary: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.3 nTPM
basal ganglia: 0.8 nTPM
midbrain: 0.8 nTPM
hypothalamus: 0.7 nTPM
medulla oblongata: 0.7 nTPM
pons: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.63
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51B4 as an antibody target. Whether an autoantibody or antibody against OR51B4 could matter depends on whether native OR51B4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51B4 is annotated at the cell surface, where native OR51B4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51B4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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