Seroatlas · Human Serome Atlas

OR51B2

Olfactory receptor 51B2

Also known as: O51B2_HUMAN, OR51B1P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5P1
Gene
OR51B2
Ensembl
ENSG00000279012
Chromosome
11
Canonical length
312 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q9Y5P1|OR51B2
     1  MWPNITAAPF LLTGFPGLEA AHHWISIPFF AVYVCILLGN GMLLYLIKHD HSLHEPMYYF
    61  LTMLAGTDLM VTLTTMPTVM GILWVNHREI SSVGCFLQAY FIHSLSVVES GSLLAMAYDC
   121  FIAIRNPLRY ASILTNTRVI ALGVGVFLRG FVSILPVILR LFSFSYCKSH VITRAFCLHQ
   181  EIMRLACADI TFNRLYPVIL ISLTIFLDCL IILFSYILIL NTVIGIASGE ERAKALNTCI
   241  SHISCVLIFY VTVMGLTFIY RFGKNVPEVV HIIMSYIYFL FPPLMNPVIY SIKTKQIQYG
   301  IIRLLSKHRF SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.3 nTPM
  • basal ganglia: 0.9 nTPM
  • medulla oblongata: 0.7 nTPM
  • spinal cord: 0.6 nTPM
  • white matter: 0.6 nTPM
  • hypothalamus: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.68
gnomAD pLI
0.01
gnomAD missense Z
-0.95

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51B2 as an antibody target. Whether an autoantibody or antibody against OR51B2 could matter depends on whether native OR51B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51B2 is annotated at the cell surface, where native OR51B2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OR51B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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