Seroatlas · Human Serome Atlas

OR51A4

Olfactory receptor 51A4

Also known as: O51A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGJ6
Gene: OR51A4
Ensembl: ENSG00000205497
Chromosome: 11
Canonical length: 313 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NGJ6|OR51A4
     1  MSIINTSYVE ITTFFLVGMP GLEYAHIWIS IPICSMYLIA ILGNGTILFI IKTEPSLHEP
    61  MYYFLSMLAM SDLGLSLSSL PTVLSIFLFN APEISSNACF AQEFFIHGFS VLESSVLLIM
   121  SFDRFLAIHN PLRYTSILTT VRVAQIGIVF SFKSMLLVLP FPFTLRNLRY CKKNQLSHSY
   181  CLHQDVMKLA CSDNRIDVIY GFFGALCLMV DFILIAVSYT LILKTVLGIA SKKEQLKALN
   241  TCVSHICAVI IFYLPIINLA VVHRFARHVS PLINVLMANV LLLVPPLTNP IVYCVKTKQI
   301  RVRVVAKLCQ RKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

neutrophils: 0.5 nCPM
vascular smooth muscle cells: 0.3 nCPM
cardiomyocytes: 0.2 nCPM
müller glia: 0.1 nCPM
myonuclei: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.3 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -1.43
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to lipid

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51A4 as an antibody target. Whether an autoantibody or antibody against OR51A4 could matter depends on whether native OR51A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51A4 is annotated at the cell surface, where native OR51A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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