Seroatlas · Human Serome Atlas

OR51A2

Olfactory receptor 51A2

Also known as: O51A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGJ7
Gene: OR51A2
Ensembl: ENSG00000205496
Chromosome: 11
Canonical length: 313 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NGJ7|OR51A2
     1  MSIINTSYVE ITTFFLVGMP GLEYAHIWIS IPICSMYLIA ILGNGTILFI IKTEPSLHGP
    61  MYYFLSMLAM SDLGLSLSSL PTVLSIFLFN APETSSSACF AQEFFIHGFS VLESSVLLIM
   121  SFDRFLAIHN PLRYTSILTT VRVAQIGIVF SFKSMLLVLP FPFTLRSLRY CKKNQLSHSY
   181  CLHQDVMKLA CSDNRIDVIY GFFGALCLMV DFILIAVSYT LILKTVPGIA SKKEELKALN
   241  TCVSHICAVI IFYLPIINLA VVHRFAGHVS PLINVLMANV LLLVPPLMKP IVYCVKTKQI
   301  RVRVVAKLCQ WKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR51A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.42
DepMap mean gene effect: 0.1
DepMap dependency class: none

OntologyGO

Biological processes

cellular response to lipid

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR51A2 as an antibody target. Whether an autoantibody or antibody against OR51A2 could matter depends on whether native OR51A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR51A2 is annotated at the cell surface, where native OR51A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR51A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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