Seroatlas · Human Serome Atlas

OR11L1

Olfactory receptor 11L1

Also known as: O11L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGX0
Gene: OR11L1
Ensembl: ENSG00000197591
Chromosome: 1
Canonical length: 322 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q8NGX0|OR11L1
     1  MEPQNTSTVT NFQLLGFQNL LEWQALLFVI FLLIYCLTII GNVVIITVVS QGLRLHSPMY
    61  MFLQHLSFLE VWYTSTTVPL LLANLLSWGQ AISFSACMAQ LYFFVFLGAT ECFLLAFMAY
   121  DRYLAICSPL RYPFLMHRGL CARLVVVSWC TGVSTGFLPS LMISRLDFCG RNQINHFFCD
   181  LPPLMQLSCS RVYITEVTIF ILSIAVLCIC FFLTLGPYVF IVSSILRIPS TSGRRKTFST
   241  CGSHLAVVTL YYGTMISMYV CPSPHLLPEI NKIISVFYTV VTPLLNPVIY SLRNKDFKEA
   301  VRKVMRRKCG ILWSTSKRKF LY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR11L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.4 nTPM
medulla oblongata: 0.3 nTPM
amygdala: 0.2 nTPM
hypothalamus: 0.2 nTPM
midbrain: 0.2 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0.05
gnomAD missense Z: -0.35
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR11L1 as an antibody target. Whether an autoantibody or antibody against OR11L1 could matter depends on whether native OR11L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR11L1 is annotated at the cell surface, where native OR11L1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR11L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...