Seroatlas · Human Serome Atlas

OR11H4

Olfactory receptor 11H4

Also known as: O11H4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGC9
Gene: OR11H4
Canonical length: 324 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR11H4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q8NGC9|OR11H4
     1  MSFFFVDLRP MNRSATHIVT EFILLGFPGC WKIQIFLFSL FLVIYVLTLL GNGAIIYAVR
    61  CNPLLHTPMY FLLGNFAFLE IWYVSSTIPN MLVNILSKTK AISFSGCFLQ FYFFFSLGTT
   121  ECLFLAVMAY DRYLAICHPL QYPAIMTVRF CGKLVSFCWL IGFLGYPIPI FYISQLPFCG
   181  PNIIDHFLCD MDPLMALSCA PAPITECIFY TQSSLVLFFT SMYILRSYIL LLTAVFQVPS
   241  AAGRRKAFST CGSHLVVVSL FYGTVMVMYV SPTYGIPTLL QKILTLVYSV TTPLFNPLIY
   301  TLRNKDMKLA LRNVLFGMRI RQNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR11H4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

gastric chief cells: 1.1 nCPM
sertoli cells: 1.1 nCPM
b-cells: 0.3 nCPM
macrophages: 0.3 nCPM
respiratory ciliated cells: 0.2 nCPM
adipocytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
basal ganglia: 0.3 nTPM
white matter: 0.3 nTPM
amygdala: 0.2 nTPM
cerebellum: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -1.22
DepMap mean gene effect: -0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR11H4 as an antibody target. Whether an autoantibody or antibody against OR11H4 could matter depends on whether native OR11H4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR11H4 is annotated at the cell surface, where native OR11H4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR11H4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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