Seroatlas · Human Serome Atlas

OR11H2

Olfactory receptor 11H2

Also known as: C14orf15, O11H2_HUMAN, OR11H2P, OR11H8P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NH07
Gene
OR11H2
Ensembl
ENSG00000258453
Chromosome
14
Canonical length
326 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q8NH07|OR11H2
     1  MCPLTLHVTG LMNVSEPNSS FAFVNEFILQ GFSCEWTIQI FLFSLFTTIY ALTITGNGAI
    61  AFVLWCDRRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF LSEKKNISFA GCFLQFYFFF
   121  SLGTSECLLL TVMAFDQYLA ICRPLLYPNI MTGHLYAKLV ILCWVCGFLW FLIPIVLISQ
   181  KPFCGPNIID HVVCDPGPLF ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV
   241  LGMPSSTGRH KAFSTCGSHL AVVSLCYSPL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF
   301  NPLIYSLQNK EIKAALRKVL GSSNII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR11H2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • adrenal cortex cells: 0.4 nCPM
  • basal keratinocytes: 0.3 nCPM
  • adipocytes: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • spinal cord: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR11H2 as an antibody target. Whether an autoantibody or antibody against OR11H2 could matter depends on whether native OR11H2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR11H2 is annotated at the cell surface, where native OR11H2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR11H2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OR11H2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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