Seroatlas · Human Serome Atlas

OR11G2

Olfactory receptor 11G2

Also known as: O11G2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGC1
Gene: OR11G2
Canonical length: 345 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR11G2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q8NGC1|OR11G2
     1  MHFLSQNDLN INLIPHLCLH RHSVIAGAFT IHRHMKIFNS PSNSSTFTGF ILLGFPCPRE
    61  GQILLFVLFT VVYLLTLMGN GSIICAVHWD QRLHAPMYIL LANFSFLEIC YVTSTVPSML
   121  ANFLSDTKII SFSGCFLQFY FFFSLGSTEC FFLAVMAFDR YLAICRPLRY PTIMTRRLCT
   181  NLVVNCWVLG FIWFLIPIVN ISQMSFCGSR IIDHFLCDPA PLLTLTCKKG PVIELVFSVL
   241  SPLPVFMLFL FIVGSYALVV RAVLRVPSAA GRRKAFSTCG SHLAVVSLFY GSVLVMYGSP
   301  PSKNEAGKQK TVTLFYSVVT PLLNPVIYSL RNKDMRKALK KFWGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR11G2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 0.2 nTPM
bone marrow: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

epicardial cells: 2.3 nCPM
gastric chief cells: 1.1 nCPM
undifferentiated spermatogonia: 0.5 nCPM
foveolar cells: 0.4 nCPM
salivary ionocytes: 0.4 nCPM
peritubular myoid cells: 0.3 nCPM

Immune cell

neutrophil: 2.2 nTPM
basophil: 0.4 nTPM
eosinophil: 0.4 nTPM
classical monocyte: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

cerebellum: 0.9 nTPM
white matter: 0.9 nTPM
cerebral cortex: 0.8 nTPM
medulla oblongata: 0.8 nTPM
midbrain: 0.8 nTPM
pons: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: 0.23

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR11G2 as an antibody target. Whether an autoantibody or antibody against OR11G2 could matter depends on whether native OR11G2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR11G2 is annotated at the cell surface, where native OR11G2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR11G2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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