OGG1

Protein identityUniProt · HPA

UniProt accession

O15527

Gene

OGG1

Ensembl

ENSG00000114026

Chromosome

3

Canonical length

345 aa

Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>O15527|OGG1
     1  MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA
    61  DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF
   121  QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG
   181  FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL
   241  CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG
   301  NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OGG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

26 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OGG1.

Disease | AllUniProt

Conditions OGG1 is implicated in, by any mechanism.

• Renal cell carcinoma (RCC) MIM:144700

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.3

gnomAD pLI

0

gnomAD missense Z

-0.57

DepMap mean gene effect

0.12

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• base-excision repair
• base-excision repair, AP site formation
• cellular response to reactive oxygen species
• depurination
• depyrimidination
• DNA damage response
• nucleotide-excision repair
• positive regulation of gene expression via chromosomal CpG island demethylation
• positive regulation of transcription by RNA polymerase II
• regulation of DNA-templated transcription
• response to oxidative stress
• response to radiation
• negative regulation of double-strand break repair via single-strand annealing

Molecular functions

• 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
• class I DNA-(apurinic or apyrimidinic site) endonuclease activity
• damaged DNA binding
• DNA binding
• endonuclease activity
• enzyme binding
• microtubule binding
• oxidized purine DNA binding
• oxidized purine nucleobase lesion DNA N-glycosylase activity
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• cytosol
• mitochondrial matrix
• mitochondrion
• nuclear matrix
• nuclear speck
• nucleoplasm
• nucleus
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• HhH-GPD domain
• DNA glycosylase
• Helix-hairpin-helix, base-excision DNA repair, C-terminal
• HhH-GPD superfamily base excision DNA repair protein
• 8-oxoguanine DNA-glycosylase
• 8-oxoguanine DNA glycosylase, N-terminal
• Oxidative DNA damage repair enzyme
• 8-oxoguanine DNA glycosylase, N-terminal domain

KeywordsUniProt

• DNA damage
• DNA repair
• Glycosidase
• Hydrolase
• Lyase
• Mitochondrion
• Multifunctional enzyme
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of OGG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RPS3