Seroatlas · Human Serome Atlas

OGFOD3

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

Also known as: C17orf101, FLJ22222, OGFD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PK18
Gene
OGFOD3
Ensembl
ENSG00000181396
Chromosome
17
Canonical length
319 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable several functions, including L-ascorbic acid binding activity; dioxygenase activity; and iron ion binding activity. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>Q6PK18|OGFOD3
     1  MAPQRRAATK APEGNGAAER RNRSSTKKDR APREVQRLWQ RPWLRTAGLG AGFVLTALLL
    61  WSSLGADDGV AEVLARRGEV VAGRFIEVPC SEDYDSHRRF EGCTPRKCGR GVTDVVITRE
   121  EAERIRSVAE KGLSLGGSDG GASILDLHSG ALSVGKHFVN LYRYFGDKIQ NIFSEEDFRL
   181  YREVRQKVQL TIAEAFGISA SSLHLTKPTF FSRINSTEAR TAHDEYWHAH VDKVTYGSFD
   241  YTSLLYLSNY LEDFGGGRFM FMEEGANKTV EPRAGRVSFF TSGSENLHRV EKVHWGTRYA
   301  ITIAFSCNPD HGIEDPAFP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OGFOD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 26 nTPM
  • pancreas: 24 nTPM
  • skeletal muscle: 23 nTPM
  • heart muscle: 23 nTPM
  • pituitary gland: 21 nTPM
  • liver: 20 nTPM

Single-cell type

  • extravillous trophoblasts: 81 nCPM
  • late spermatids: 71 nCPM
  • epididymal principal cells: 58 nCPM
  • decidual stromal cells: 58 nCPM
  • oocytes: 55 nCPM
  • pancreatic islet cells: 55 nCPM

Immune cell

  • myeloid DC: 24 nTPM
  • classical monocyte: 14 nTPM
  • memory B-cell: 14 nTPM
  • memory CD8 T-cell: 13 nTPM
  • intermediate monocyte: 13 nTPM
  • plasmacytoid DC: 12 nTPM

Brain region

  • choroid plexus: 26 nTPM
  • cerebellum: 18 nTPM
  • medulla oblongata: 17 nTPM
  • cerebral cortex: 16 nTPM
  • white matter: 16 nTPM
  • pons: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
0.56
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OGFOD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OGFOD3 as an antibody target. Whether an autoantibody or antibody against OGFOD3 could matter depends on whether native OGFOD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OGFOD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OGFOD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OGFOD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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