ODAM
Odontogenic ameloblast-associated protein
Also known as: APin, FLJ20513, ODAM_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A1E959
- Gene
- ODAM
- Ensembl
- ENSG00000109205
- Chromosome
- 4
- Canonical length
- 279 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Involved in several processes, including positive regulation of GTPase activity; positive regulation of epithelial cell proliferation involved in wound healing; and positive regulation of macromolecule metabolic process. Located in several cellular components, including extracellular space; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
279 residues, UniProt reviewed canonical sequence.
>A1E959|ODAM
1 MKIIILLGFL GATLSAPLIP QRLMSASNSN ELLLNLNNGQ LLPLQLQGPL NSWIPPFSGI
61 LQQQQQAQIP GLSQFSLSAL DQFAGLLPNQ IPLTGEASFA QGAQAGQVDP LQLQTPPQTQ
121 PGPSHVMPYV FSFKMPQEQG QMFQYYPVYM VLPWEQPQQT VPRSPQQTRQ QQYEEQIPFY
181 AQFGYIPQLA EPAISGGQQQ LAFDPQLGTA PEIAVMSTGE EIPYLQKEAI NFRHDSAGVF
241 MPSTSPKPST TNVFTSAVDQ TITPELPEEK DKTDSLREPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ODAM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.72
- Highest tissue expression
- 320 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 320 nTPM
- stomach: 9.3 nTPM
- smooth muscle: 6.1 nTPM
- thyroid gland: 3.6 nTPM
- parathyroid gland: 3.4 nTPM
- appendix: 2.6 nTPM
Single-cell type
- salivary acinar cells: 336 nCPM
- parietal cells: 251 nCPM
- lacrimal acinar cells: 224 nCPM
- submucosal glandular cells: 103 nCPM
- breast lactating cells: 102 nCPM
- salivary myoepithelial cells: 74 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 2.5 nTPM
- hypothalamus: 1.6 nTPM
- midbrain: 1.5 nTPM
- thalamus: 0.5 nTPM
- choroid plexus: 0.2 nTPM
- white matter: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.52
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.47
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- biomineral tissue development
- inflammatory response
- odontogenesis of dentin-containing tooth
- positive regulation of epithelial cell proliferation involved in wound healing
- positive regulation of gene expression
- positive regulation of GTPase activity
- positive regulation of protein phosphorylation
- regulation of actin cytoskeleton organization
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Odontogenic ameloblast-associated protein
- Odontogenic ameloblast-associated family
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ODAM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ODAM as an antibody target. Whether an autoantibody or antibody against ODAM could matter depends on whether native ODAM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ODAM is annotated as secreted, so native ODAM circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ODAM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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