Seroatlas · Human Serome Atlas

ODAD2

Outer dynein arm-docking complex subunit 2

Also known as: ARMC4, CILD23, DKFZP434P1735, FLJ10376, FLJ10817, gudu, ODAD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T2S8
Gene: ODAD2
Ensembl: ENSG00000169126
Chromosome: 10
Canonical length: 1044 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Acrosome,Principal piece,End piece

OverviewNCBI Gene

The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

1044 residues, UniProt reviewed canonical sequence.

>Q5T2S8|ODAD2
     1  MGVALRKLTQ WTAAGHGTGI LEITPLNEAI LKEIIVFVES FIYKHPQEAK FVFVEPLEWN
    61  TSLAPSAFES GYVVSETTVK SEEVDKNGQP LLFLSVPQIK IRSFGQLSRL LLIAKTGKLK
   121  EAQACVEANR DPIVKILGSD YNTMKENSIA LNILGKITRD DDPESEIKMK IAMLLKQLDL
   181  HLLNHSLKHI SLEISLSPMT VKKDIELLKR FSGKGNQTVL ESIEYTSDYE FSNGCRAPPW
   241  RQIRGEICYV LVKPHDGETL CITCSAGGVF LNGGKTDDEG DVNYERKGSI YKNLVTFLRE
   301  KSPKFSENMS KLGISFSEDQ QKEKDQLGKA PKKEEAAALR KDISGSDKRS LEKNQINFWR
   361  NQMTKRWEPS LNWKTTVNYK GKGSAKEIQE DKHTGKLEKP RPSVSHGRAQ LLRKSAEKIE
   421  ETVSDSSSES EEDEEPPDHR QEASADLPSE YWQIQKLVKY LKGGNQTATV IALCSMRDFS
   481  LAQETCQLAI RDVGGLEVLI NLLETDEVKC KIGSLKILKE ISHNPQIRQN IVDLGGLPIM
   541  VNILDSPHKS LKCLAAETIA NVAKFKRARR VVRQHGGITK LVALLDCAHD STKPAQSSLY
   601  EARDVEVARC GALALWSCSK SHTNKEAIRK AGGIPLLARL LKTSHENMLI PVVGTLQECA
   661  SEENYRAAIK AERIIENLVK NLNSENEQLQ EHCAMAIYQC AEDKETRDLV RLHGGLKPLA
   721  SLLNNTDNKE RLAAVTGAIW KCSISKENVT KFREYKAIET LVGLLTDQPE EVLVNVVGAL
   781  GECCQERENR VIVRKCGGIQ PLVNLLVGIN QALLVNVTKA VGACAVEPES MMIIDRLDGV
   841  RLLWSLLKNP HPDVKASAAW ALCPCIKNAK DAGEMVRSFV GGLELIVNLL KSDNKEVLAS
   901  VCAAITNIAK DQENLAVITD HGVVPLLSKL ANTNNNKLRH HLAEAISRCC MWGRNRVAFG
   961  EHKAVAPLVR YLKSNDTNVH RATAQALYQL SEDADNCITM HENGAVKLLL DMVGSPDQDL
  1021  QEAAAGCISN IRRLALATEK ARYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ODAD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

testis: 38 nTPM
fallopian tube: 22 nTPM
choroid plexus: 7.5 nTPM
pituitary gland: 7.5 nTPM
prostate: 2.9 nTPM
hypothalamus: 2.5 nTPM

Single-cell type

respiratory ciliated cells: 653 nCPM
ependymal cells: 573 nCPM
early spermatids: 399 nCPM
fallopian tube ciliated cells: 353 nCPM
late primary spermatocytes: 353 nCPM
gonadotrophs: 212 nCPM

Immune cell

naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 20 nTPM
midbrain: 10 nTPM
medulla oblongata: 9.9 nTPM
spinal cord: 7.4 nTPM
white matter: 5.6 nTPM
pons: 4.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ODAD2.

Disease | AllUniProt

Conditions ODAD2 is implicated in, by any mechanism.

Ciliary dyskinesia, primary, 23 (CILD23) MIM:615451

Disease | GeneticClinVar

66 pathogenic / likely-pathogenic of 780 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Primary ciliary dyskinesia 23
Primary ciliary dyskinesia
Male infertility
Kartagener syndrome
Fetal anomalies with a likely genetic cause

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ODAD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CFAP61

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ODAD2 as an antibody target. Whether an autoantibody or antibody against ODAD2 could matter depends on whether native ODAD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ODAD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ODAD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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