Seroatlas · Human Serome Atlas

NXPE4

NXPE family member 4

Also known as: C11orf33, FAM55D, FLJ20127, NXPE4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWF7
Gene: NXPE4
Ensembl: ENSG00000137634
Chromosome: 11
Canonical length: 544 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>Q6UWF7|NXPE4
     1  MKISMINYKS LLALLFILAS WIIFTVFQNS TKVWSALNLS ISLHYWNNST KSLFPKTPLI
    61  SLKPLTETEL RIKEIIEKLD QQIPPRPFTH VNTTTSATHS TATILNPRDT YCRGDQLHIL
   121  LEVRDHLGRR KQYGGDFLRA RMSSPALMAG ASGKVTDFNN GTYLVSFTLF WEGQVSLSLL
   181  LIHPSEGVSA LWSARNQGYD RVIFTGQFVN GTSQVHSECG LILNTNAELC QYLDNRDQEG
   241  FYCVRPQHMP CAALTHMYSK NKKVSYLSKQ EKSLFERSNV GVEIMEKFNT ISVSKCNKET
   301  VAMKEKCKFG MTSTIPSGHV WRNTWNPVSC SLATVKMKEC LRGKLIYLMG DSTIRQWMEY
   361  FKASINTLKS VDLHESGKLQ HQLAVDLDRN INIQWQKYCY PLIGSMTYSV KEMEYLTRAI
   421  DRTGGEKNTV IVISLGQHFR PFPIDVFIRR ALNVHKAIQH LLLRSPDTMV IIKTENIREM
   481  YNDAERFSDF HGYIQYLIIK DIFQDLSVSI IDAWDITIAY GTNNVHPPQH VVGNQINILL
   541  NYIC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXPE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

rectum: 112 nTPM
colon: 107 nTPM
salivary gland: 73 nTPM
appendix: 7.3 nTPM
epididymis: 6.4 nTPM
prostate: 5 nTPM

Single-cell type

colonocytes: 169 nCPM
enteric stem cells: 127 nCPM
enteric transient amplifying cells: 110 nCPM
goblet cells: 102 nCPM
salivary acinar cells: 68 nCPM
cardiomyocytes: 22 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.9 nTPM
cerebral cortex: 0.8 nTPM
hypothalamus: 0.8 nTPM
medulla oblongata: 0.8 nTPM
white matter: 0.8 nTPM
amygdala: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXPE4 as an antibody target. Whether an autoantibody or antibody against NXPE4 could matter depends on whether native NXPE4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXPE4 is annotated as secreted, so native NXPE4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NXPE4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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