Seroatlas · Human Serome Atlas

NXPE3

NXPE family member 3

Also known as: FAM55C, MGC15606, NXPE3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969Y0
Gene: NXPE3
Ensembl: ENSG00000144815
Chromosome: 3
Canonical length: 559 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q969Y0|NXPE3
     1  MWTNFFKLRL FCCLLAVLMV VVLVINVTQV EYLDHETVSA TFIDSSGQFV SSQVTGISRN
    61  PYCGYDQQTL SSQERMEEDS LLAALHRQVP DVGPVPFVKS TDPSSSYFVI LNSAAFFKVG
   121  SQLEVLVHVQ DFQRKPKKYG GDYLQARIHS LKLQAGAVGR VVDYQNGFYK VFFTLLWPGK
   181  VKVSVSLVHP SEGIRVLQRL QEDKPDRVYF KSLFRSGRIS ETTECNVCLP GNLPLCNFTD
   241  LYTGEPWFCF KPKKLPCSSR ITHFKGGYLK GLLTAAESAF FQSGVNIKMP VNSSGPDWVT
   301  VIPRRIKETN SLELSQGSGT FPSGYYYKDQ WRPRKFKMRQ FNDPDNITEC LQRKVVHLFG
   361  DSTIRQWFEY LTTFVPDLVE FNLGSPKNVG PFLAVDQKHN ILLKYRCHGP PIRFTTVFSN
   421  ELHYVANELN GIVGGKNTVV AIAVWSHFST FPLEVYIRRL RNIRRAVVRL LDRSPKTVVV
   481  IRTANAQELG PEVSLFNSDW YNFQLDTILR RMFSGVGVYL VDAWEMTLAH YLPHKLHPDE
   541  VIVKNQLDMF LSFVCPLET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXPE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 56 nTPM
tongue: 48 nTPM
parathyroid gland: 18 nTPM
heart muscle: 15 nTPM
spinal cord: 12 nTPM
lymph node: 12 nTPM

Single-cell type

oligodendrocytes: 221 nCPM
myonuclei: 149 nCPM
plasma cells: 131 nCPM
neutrophil progenitors: 89 nCPM
cardiomyocytes: 62 nCPM
oligodendrocyte progenitor cells: 62 nCPM

Immune cell

naive CD4 T-cell: 17 nTPM
T-reg: 16 nTPM
eosinophil: 16 nTPM
naive CD8 T-cell: 14 nTPM
memory CD4 T-cell: 13 nTPM
classical monocyte: 13 nTPM

Brain region

white matter: 62 nTPM
pons: 58 nTPM
thalamus: 56 nTPM
basal ganglia: 52 nTPM
midbrain: 52 nTPM
medulla oblongata: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.01
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXPE3 as an antibody target. Whether an autoantibody or antibody against NXPE3 could matter depends on whether native NXPE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXPE3 is annotated as secreted, so native NXPE3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NXPE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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