Seroatlas · Human Serome Atlas

NXPE2

NXPE family member 2

Also known as: FAM55B, FLJ25224, NXPE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DL1
Gene: NXPE2
Ensembl: ENSG00000204361
Chromosome: 11
Canonical length: 559 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q96DL1|NXPE2
     1  MVEKILIHRI LTLFPNAIAR KLLLMLTFIL IFWIIYLASK DHTKFSFNLE NHIILNQGNI
    61  FKKYSHSETP LCPAVSPKET ELRIKDIMEK LDQQIPPRPF THVNTTTSAT HSTATILNPQ
   121  DTYCRGDQLD ILLEVRDHLG HRKQYGGDFL RARMYSTALM AGASGKVTDF NNGTYLVSFT
   181  LFWEGQVSLS LLLIHPSEGV SALWRARNQG CDRIIFTGLF ANRSSNVFTE CGLTLNTNAE
   241  LCQYMDDRDQ EAFYCVRPQH MPCEALTHMT TRTRNISYLS KEEWRLFHRS NIGVEMMKNF
   301  TPIEVIPCNK SENIKKNCQI GMKTPFPSGY TLKKMWITAF CKQIKFNETK NINDCLERKL
   361  IYLMGDSTLH QWIYYLQKAV KTLKYFDHHG AGIFKTHVLL DVERHILIQW KKHGHPFVTK
   421  KLFSVKDENY IPREIDQVAG DKNTAIVITL GQHFRPFPIN IFIRRAINIQ KAIERLFLRS
   481  PETKVILKTE NTREIEQNAE MFSDFHGYIQ NLIIRDIFVD LNVGIIDAWD MTIAYCTNNA
   541  HPPDYVIQNQ IGMFLNYIC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXPE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

epididymis: 24 nTPM
salivary gland: 20 nTPM
colon: 9.2 nTPM
rectum: 8.6 nTPM
small intestine: 2.5 nTPM
appendix: 1 nTPM

Single-cell type

salivary acinar cells: 51 nCPM
epididymal principal cells: 44 nCPM
goblet cells: 36 nCPM
colonocytes: 13 nCPM
neuroendocrine cells: 12 nCPM
submucosal glandular cells: 11 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.1 nTPM
midbrain: 1 nTPM
pons: 1 nTPM
medulla oblongata: 0.8 nTPM
cerebral cortex: 0.7 nTPM
white matter: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXPE2 as an antibody target. Whether an autoantibody or antibody against NXPE2 could matter depends on whether native NXPE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXPE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NXPE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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