Seroatlas · Human Serome Atlas

NXPE1

NXPE family member 1

Also known as: FAM55A, MGC34290, NXPE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N323
Gene: NXPE1
Ensembl: ENSG00000095110
Chromosome: 11
Canonical length: 547 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to be located in extracellular region and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q8N323|NXPE1
     1  MSSNTMLQKT LLILISFSVV TWMIFIISQN FTKLWSALNL SISVHYWNNS AKSLFPKTSL
    61  IPLKPLTETE LRIKEIIEKL DQQIPPRPFT HVNTTTSATH STATILNPRD TYCRGDQLDI
   121  LLEVRDHLGQ RKQYGGDFLR ARMSSPALTA GASGKVMDFN NGTYLVSFTL FWEGQVSLSL
   181  LLIHPSEGAS ALWRARNQGY DKIIFKGKFV NGTSHVFTEC GLTLNSNAEL CEYLDDRDQE
   241  AFYCMKPQHM PCEALTYMTT RNREVSYLTD KENSLFHRSK VGVEMMKDRK HIDVTNCNKR
   301  EKIEETCQVG MKPPVPGGYT LQGKWITTFC NQVQLDTIKI NGCLKGKLIY LLGDSTLRQW
   361  IYYFPKVVKT LKFFDLHETG IFKKHLLLDA ERHTQIQWKK HSYPFVTFQL YSLIDHDYIP
   421  REIDRLSGDK NTAIVITFGQ HFRPFPIDIF IRRAIGVQKA IERLFLRSPA TKVIIKTENI
   481  REMHIETERF GDFHGYIHYL IMKDIFKDLN VGIIDAWDMT IAYGTDTIHP PDHVIGNQIN
   541  MFLNYIC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXPE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

rectum: 70 nTPM
colon: 57 nTPM
appendix: 4.6 nTPM
testis: 4 nTPM
small intestine: 3.2 nTPM
smooth muscle: 2.1 nTPM

Single-cell type

goblet cells: 586 nCPM
colonocytes: 535 nCPM
enteric stem cells: 308 nCPM
enteric transient amplifying cells: 277 nCPM
late spermatids: 102 nCPM
late primary spermatocytes: 81 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 2.9 nTPM
white matter: 2.9 nTPM
hypothalamus: 2.7 nTPM
medulla oblongata: 2.7 nTPM
cerebral cortex: 2.5 nTPM
midbrain: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXPE1 as an antibody target. Whether an autoantibody or antibody against NXPE1 could matter depends on whether native NXPE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXPE1 is annotated as secreted, so native NXPE1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NXPE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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