Seroatlas · Human Serome Atlas

NXNL2

Nucleoredoxin-like protein 2

Also known as: C9orf121, NXNL2_HUMAN, RdCVF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZ03
Gene: NXNL2
Ensembl: ENSG00000130045
Chromosome: 9
Canonical length: 156 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be involved in sensory perception of smell and visual perception. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>Q5VZ03|NXNL2
     1  MVDILGERHL VTCKGATVEA EAALQNKVVA LYFAAARCAP SRDFTPLLCD FYTALVAEAR
    61  RPAPFEVVFV SADGSSQEML DFMRELHGAW LALPFHDPYR HELRKRYNVT AIPKLVIVKQ
   121  NGEVITNKGR KQIRERGLAC FQDWVEAADI FQNFSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXNL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 14 nTPM
cervix: 9.6 nTPM
endometrium: 5.5 nTPM
retina: 4.8 nTPM
bone marrow: 3.7 nTPM
ovary: 3.7 nTPM

Single-cell type

fallopian secretory cells: 80 nCPM
epididymal efferent duct absorptive cells: 78 nCPM
endometrial ciliated cells: 63 nCPM
fallopian tube ciliated cells: 59 nCPM
epididymal efferent duct ciliated cells: 45 nCPM
endometrial secretory cells: 43 nCPM

Immune cell

basophil: 2 nTPM
neutrophil: 1.1 nTPM
eosinophil: 0.7 nTPM
memory CD8 T-cell: 0.6 nTPM
naive CD8 T-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM

Brain region

white matter: 39 nTPM
hypothalamus: 38 nTPM
cerebral cortex: 38 nTPM
cerebellum: 37 nTPM
basal ganglia: 37 nTPM
choroid plexus: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0.68
gnomAD missense Z: -0.17
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXNL2 as an antibody target. Whether an autoantibody or antibody against NXNL2 could matter depends on whether native NXNL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXNL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NXNL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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