Seroatlas · Human Serome Atlas

NUP155

Nuclear pore complex protein Nup155

Also known as: KIAA0791, N155, NU155_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75694
Gene: NUP155
Ensembl: ENSG00000113569
Chromosome: 5
Canonical length: 1391 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location: Nuclear membrane

OverviewNCBI Gene

Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

1391 residues, UniProt reviewed canonical sequence.

>O75694|NUP155
     1  MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS APNNPTVSGM
    61  SDMDYPLQGP GLLSVPNLPE ISSIRRVPLP PELVEQFGHM QCNCMMGVFP PISRAWLTID
   121  SDIFMWNYED GGDLAYFDGL SETILAVGLV KPKAGIFQPH VRHLLVLATP VDIVILGLSY
   181  ANLQTGSGVL NDSLSGGMQL LPDPLYSLPT DNTYLLTITS TDNGRIFLAG KDGCLYEVAY
   241  QAEAGWFSQR CRKINHSKSS LSFLVPSLLQ FTFSEDDPIL QIAIDNSRNI LYTRSEKGVI
   301  QVYDLGQDGQ GMSRVASVSQ NAIVSAAGNI ARTIDRSVFK PIVQIAVIEN SESLDCQLLA
   361  VTHAGVRLYF STCPFRQPLA RPNTLTLVHV RLPPGFSASS TVEKPSKVHR ALYSKGILLM
   421  AASENEDNDI LWCVNHDTFP FQKPMMETQM TAGVDGHSWA LSAIDELKVD KIITPLNKDH
   481  IPITDSPVVV QQHMLPPKKF VLLSAQGSLM FHKLRPVDQL RHLLVSNVGG DGEEIERFFK
   541  LHQEDQACAT CLILACSTAA CDREVSAWAT RAFFRYGGEA QMRFPTTLPP PSNVGPILGS
   601  PVYSSSPVPS GSPYPNPSFL GTPSHGIQPP AMSTPVCALG NPATQATNMS CVTGPEIVYS
   661  GKHNGICIYF SRIMGNIWDA SLVVERIFKS GNREITAIES SVPCQLLESV LQELKGLQEF
   721  LDRNSQFAGG PLGNPNTTAK VQQRLIGFMR PENGNPQQMQ QELQRKFHEA QLSEKISLQA
   781  IQQLVRKSYQ ALALWKLLCE HQFTIIVAEL QKELQEQLKI TTFKDLVIRD KELTGALIAS
   841  LINCYIRDNA AVDGISLHLQ DICPLLYSTD DAICSKANEL LQRSRQVQNK TEKERMLRES
   901  LKEYQKISNQ VDLSNVCAQY RQVRFYEGVV ELSLTAAEKK DPQGLGLHFY KHGEPEEDIV
   961  GLQAFQERLN SYKCITDTLQ ELVNQSKAAP QSPSVPKKPG PPVLSSDPNM LSNEEAGHHF
  1021  EQMLKLSQRS KDELFSIALY NWLIQVDLAD KLLQVASPFL EPHLVRMAKV DQNRVRYMDL
  1081  LWRYYEKNRS FSNAARVLSR LADMHSTEIS LQQRLEYIAR AILSAKSSTA ISSIAADGEF
  1141  LHELEEKMEV ARIQLQIQET LQRQYSHHSS VQDAVSQLDS ELMDITKLYG EFADPFKLAE
  1201  CKLAIIHCAG YSDPILVQTL WQDIIEKELS DSVTLSSSDR MHALSLKIVL LGKIYAGTPR
  1261  FFPLDFIVQF LEQQVCTLNW DVGFVIQTMN EIGVPLPRLL EVYDQLFKSR DPFWNRMKKP
  1321  LHLLDCIHVL LIRYVENPSQ VLNCERRRFT NLCLDAVCGY LVELQSMSSS VAVQAITGNF
  1381  KSLQAKLERL H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP155 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

testis: 66 nTPM
bone marrow: 14 nTPM
thymus: 12 nTPM
tonsil: 9.2 nTPM
lymph node: 7.7 nTPM
parathyroid gland: 7.6 nTPM

Single-cell type

late spermatids: 192 nCPM
erythrocyte progenitors: 86 nCPM
late primary spermatocytes: 71 nCPM
monocyte progenitors: 59 nCPM
early spermatids: 56 nCPM
adipocytes: 53 nCPM

Immune cell

MAIT T-cell: 5.6 nTPM
NK-cell: 4.5 nTPM
intermediate monocyte: 4.2 nTPM
basophil: 4.1 nTPM
memory B-cell: 3.9 nTPM
eosinophil: 3.5 nTPM

Brain region

cerebellum: 18 nTPM
white matter: 15 nTPM
choroid plexus: 14 nTPM
pons: 13 nTPM
thalamus: 13 nTPM
spinal cord: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP155.

Disease | AllUniProt

Conditions NUP155 is implicated in, by any mechanism.

Atrial fibrillation, familial, 15 (ATFB15) MIM:615770

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 302 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Atrial fibrillation, familial, 15

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.65
gnomAD missense Z: 0.81
DepMap mean gene effect: -1.16
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of nuclear pore

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleoporin, Nup133/Nup155-like, C-terminal
Non-repetitive/WGA-negative nucleoporin C-terminal
Nucleoporin, Nup155-like
Nucleoporin, Nup133/Nup155-like, N-terminal
Nucleoporin, Nup155-like, C-terminal, subdomain 1
Nucleoporin, Nup155-like, C-terminal, subdomain 2
Nucleoporin, Nup155-like, C-terminal, subdomain 3
Nup133 N terminal like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP155 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP155 as an antibody target. Whether an autoantibody or antibody against NUP155 could matter depends on whether native NUP155 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP155 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP155 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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