NUDT12

Protein identityUniProt · HPA

UniProt accession

Q9BQG2

Gene

NUDT12

Ensembl

ENSG00000112874

Chromosome

5

Canonical length

462 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q9BQG2|NUDT12
     1  MSSVKRSLKQ EIVTQFHCSA AEGDIAKLTG ILSHSPSLLN ETSENGWTAL MYAARNGHPE
    61  IVQFLLEKGC DRSIVNKSRQ TALDIAVFWG YKHIANLLAT AKGGKKPWFL TNEVEECENY
   121  FSKTLLDRKS EKRNNSDWLL AKESHPATVF ILFSDLNPLV TLGGNKESFQ QPEVRLCQLN
   181  YTDIKDYLAQ PEKITLIFLG VELEIKDKLL NYAGEVPREE EDGLVAWFAL GIDPIAAEEF
   241  KQRHENCYFL HPPMPALLQL KEKEAGVVAQ ARSVLAWHSR YKFCPTCGNA TKIEEGGYKR
   301  LCLKEDCPSL NGVHNTSYPR VDPVVIMQVI HPDGTKCLLG RQKRFPPGMF TCLAGFIEPG
   361  ETIEDAVRRE VEEESGVKVG HVQYVACQPW PMPSSLMIGC LALAVSTEIK VDKNEIEDAR
   421  WFTREQVLDV LTKGKQQAFF VPPSRAIAHQ LIKHWIRINP NL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

27 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.33

gnomAD pLI

0

gnomAD missense Z

-0.48

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• circadian regulation of gene expression
• mRNA catabolic process
• mRNA methylguanosine-cap decapping
• NAD+ catabolic process
• NAD-cap decapping
• NADP+ catabolic process
• nicotinate metabolic process

Molecular functions

• magnesium ion binding
• NAD+ diphosphatase activity
• NADH pyrophosphatase activity
• NADPH pyrophosphatase activity
• phosphodiesterase decapping endonuclease activity
• RNA NAD-cap (NMN-forming) hydrolase activity
• zinc ion binding

Cellular components

• cytoplasm
• nucleus
• peroxisomal matrix
• peroxisome

Protein domainsUniProt · Pfam · InterPro

• NUDIX hydrolase domain
• Ankyrin repeat
• NADH pyrophosphatase-like, N-terminal
• Zinc ribbon, NADH pyrophosphatase
• NUDIX hydrolase-like domain superfamily
• NUDIX hydrolase, conserved site
• Ankyrin repeat-containing domain superfamily
• NADH pyrophosphatase-like, C-terminal domain
• NAD-capped RNA hydrolase NudC subfamily
• NUDIX domain
• NADH pyrophosphatase-like rudimentary NUDIX domain
• NADH pyrophosphatase zinc ribbon domain
• Ankyrin repeats (3 copies)

KeywordsUniProt

• ANK repeat
• Cytoplasm
• Hydrolase
• Magnesium
• Metal-binding
• NAD
• NADP
• Peroxisome
• Repeat
• Zinc

InteractionsUniProt · HPA

Protein binding partners of NUDT12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BLMH
• HSPB8