Seroatlas · Human Serome Atlas

NUCB1

Nucleobindin-1

Also known as: Calnuc, NUC, NUCB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q02818
Gene: NUCB1
Ensembl: ENSG00000104805
Chromosome: 19
Canonical length: 461 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus,Vesicles,Microtubules
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q02818|NUCB1
     1  MPPSGPRGTL LLLPLLLLLL LRAVLAVPLE RGAPNKEETP ATESPDTGLY YHRYLQEVID
    61  VLETDGHFRE KLQAANAEDI KSGKLSRELD FVSHHVRTKL DELKRQEVSR LRMLLKAKMD
   121  AEQDPNVQVD HLNLLKQFEH LDPQNQHTFE ARDLELLIQT ATRDLAQYDA AHHEEFKRYE
   181  MLKEHERRRY LESLGEEQRK EAERKLEEQQ RRHREHPKVN VPGSQAQLKE VWEELDGLDP
   241  NRFNPKTFFI LHDINSDGVL DEQELEALFT KELEKVYDPK NEEDDMREME EERLRMREHV
   301  MKNVDTNQDR LVTLEEFLAS TQRKEFGDTG EGWETVEMHP AYTEEELRRF EEELAAREAE
   361  LNAKAQRLSQ ETEALGRSQG RLEAQKRELQ QAVLHMEQRK QQQQQQQGHK APAAHPEGQL
   421  KFHPDTDDVP VPAPAGDQKE VDTSEKKLLE RLPEVEVPQH L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUCB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 284 nTPM

Expression across tissuesHPA

Tissue

liver: 284 nTPM
blood vessel: 280 nTPM
heart muscle: 220 nTPM
kidney: 175 nTPM
lung: 164 nTPM
adipose tissue: 163 nTPM

Single-cell type

enterocytes: 437 nCPM
esophageal apical cells: 297 nCPM
decidual stromal cells: 282 nCPM
hofbauer cells: 257 nCPM
platelets: 226 nCPM
extravillous trophoblasts: 206 nCPM

Immune cell

total PBMC: 121 nTPM
intermediate monocyte: 121 nTPM
plasmacytoid DC: 109 nTPM
non-classical monocyte: 107 nTPM
classical monocyte: 101 nTPM
eosinophil: 98 nTPM

Brain region

choroid plexus: 114 nTPM
thalamus: 108 nTPM
pons: 99 nTPM
medulla oblongata: 99 nTPM
cerebellum: 92 nTPM
hypothalamus: 90 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.93
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

small GTPase-mediated signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUCB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NUCB2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUCB1 as an antibody target. Whether an autoantibody or antibody against NUCB1 could matter depends on whether native NUCB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUCB1 is annotated as secreted, so native NUCB1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NUCB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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