Seroatlas · Human Serome Atlas

NSMF

NMDA receptor synaptonuclear signaling and neuronal migration factor

Also known as: NELF, NSMF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6X4W1
Gene
NSMF
Ensembl
ENSG00000165802
Chromosome
9
Canonical length
530 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q6X4W1|NSMF
     1  MGAAASRRRA LRSEAMSSVA AKVRAARAFG EYLSQSHPEN RNGADHLLAD AYSGHDGSPE
    61  MQPAPQNKRR LSLVSNGCYE GSLSEEPSIR KPAGEGPQPR VYTISGEPAL LPSPEAEAIE
   121  LAVVKGRRQR HPHHHSQPLR ASPGGSREDV SRPCQSWAGS RQGSKECPGC AQLAPGPTPR
   181  AFGLDQPPLP ETSGRRKKLE RMYSVDRVSD DIPIRTWFPK ENLFSFQTAT TTMQAISVFR
   241  GYAERKRRKR ENDSASVIQR NFRKHLRMVG SRRVKAQTFA ERRERSFSRS WSDPTPMKAD
   301  TSHDSRDSSD LQSSHCTLDE AFEDLDWDTE KGLEAVACDT EGFVPPKVML ISSKVPKAEY
   361  IPTIIRRDDP SIIPILYDHE HATFEDILEE IERKLNVYHK GAKIWKMLIF CQGGPGHLYL
   421  LKNKVATFAK VEKEEDMIHF WKRLSRLMSK VNPEPNVIHI MGCYILGNPN GEKLFQNLRT
   481  LMTPYRVTFE SPLELSAQGK QMIETYFDFR LYRLWKSRQH SKLLDFDDVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSMF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
654 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 654 nTPM
  • cerebral cortex: 404 nTPM
  • amygdala: 366 nTPM
  • basal ganglia: 168 nTPM
  • blood vessel: 146 nTPM
  • hypothalamus: 126 nTPM

Single-cell type

  • ependymal cells: 192 nCPM
  • astrocytes: 120 nCPM
  • peritubular myoid cells: 84 nCPM
  • proximal tubule cells: 79 nCPM
  • bergmann glia: 77 nCPM
  • epididymal efferent duct ciliated cells: 76 nCPM

Immune cell

  • intermediate monocyte: 14 nTPM
  • non-classical monocyte: 12 nTPM
  • myeloid DC: 6.3 nTPM
  • eosinophil: 3.6 nTPM
  • classical monocyte: 2.1 nTPM
  • total PBMC: 1.8 nTPM

Brain region

  • hippocampal formation: 718 nTPM
  • cerebral cortex: 709 nTPM
  • thalamus: 400 nTPM
  • amygdala: 307 nTPM
  • midbrain: 285 nTPM
  • basal ganglia: 281 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NSMF.

Disease | AllUniProt

Conditions NSMF is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 9 with or without anosmia (HH9) MIM:614838

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 238 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.26
gnomAD missense Z
1.88
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NSMF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSMF as an antibody target. Whether an autoantibody or antibody against NSMF could matter depends on whether native NSMF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSMF is annotated at the cell surface, where native NSMF is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NSMF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NSMF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...