Seroatlas · Human Serome Atlas

NRIP2

Nuclear receptor-interacting protein 2

Also known as: DKFZP761G1913, NRIP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQI9
Gene: NRIP2
Ensembl: ENSG00000053702
Chromosome: 12
Canonical length: 281 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>Q9BQI9|NRIP2
     1  MLFIFPLSLP WRPSCWKESC STGQRQAGRS REDSVTPPPS SPWPTPPAGA MSTKQEARRD
    61  EGEARTRGQE AQLRDRAHLS QQRRLKQATQ FLHKDSADLL PLDSLKRLGT SKDLQPRSVI
   121  QRRLVEGNPN WLQGEPPRMQ DLIHGQESRR KTSRTEIPAL LVNCKCQDQL LRVAVDTGTQ
   181  YNRISAGCLS RLGLEKRVLK ASAGDLAPGP PTQVEQLELQ LGQETVVCSA QVVDAESPEF
   241  CLGLQTLLSL KCCIDLEHGV LRLKAPFSEL PFLPLYQEPG Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 56 nTPM
blood vessel: 17 nTPM
basal ganglia: 10 nTPM
cervix: 8.7 nTPM
kidney: 8.7 nTPM
ovary: 7.5 nTPM

Single-cell type

cardiomyocytes: 42 nCPM
epicardial cells: 25 nCPM
podocytes: 21 nCPM
vascular smooth muscle cells: 21 nCPM
myonuclei: 8.7 nCPM
brain excitatory neurons: 8.3 nCPM

Immune cell

basophil: 3.7 nTPM
naive CD4 T-cell: 0.8 nTPM
memory B-cell: 0.7 nTPM
naive B-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM

Brain region

cerebellum: 54 nTPM
pons: 32 nTPM
white matter: 32 nTPM
medulla oblongata: 31 nTPM
basal ganglia: 31 nTPM
thalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -1.04
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

aspartic-type endopeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NRIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NR1F2
RARA
THRB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRIP2 as an antibody target. Whether an autoantibody or antibody against NRIP2 could matter depends on whether native NRIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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