NRG2

Protein identityUniProt · HPA

UniProt accession

O14511

Gene

NRG2

Ensembl

ENSG00000158458

Chromosome

5

Canonical length

850 aa

Protein class

Cancer-related genes, Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Nucleoli

Secretome location

Secreted in other tissues

OverviewNCBI Gene

This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

850 residues, UniProt reviewed canonical sequence.

>O14511|NRG2
     1  MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA
    61  APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV
   121  QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI
   181  SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK
   241  KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK
   301  VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY
   361  YIEGINQLSC KCPNGFFGQR CLEKLPLRLY MPDPKQKAEE LYQKRVLTIT GICVALLVVG
   421  IVCVVAYCKT KKQRKQMHNH LRQNMCPAHQ NRSLANGPSH PRLDPEEIQM ADYISKNVPA
   481  TDHVIRRETE TTFSGSHSCS PSHHCSTATP TSSHRHESHT WSLERSESLT SDSQSGIMLS
   541  SVGTSKCNSP ACVEARARRA AAYNLEERRR ATAPPYHDSV DSLRDSPHSE RYVSALTTPA
   601  RLSPVDFHYS LATQVPTFEI TSPNSAHAVS LPPAAPISYR LAEQQPLLRH PAPPGPGPGP
   661  GPGPGPGADM QRSYDSYYYP AAGPGPRRGT CALGGSLGSL PASPFRIPED DEYETTQECA
   721  PPPPPRPRAR GASRRTSAGP RRWRRSRLNG LAAQRARAAR DSLSLSSGSG GGSASASDDD
   781  ADDADGALAA ESTPFLGLRG AHDALRSDSP PLCPAADSRT YYSLDSHSTR ASSRHSRGPP
   841  PRAKQDSAPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.21

gnomAD pLI

1

gnomAD missense Z

2.27

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• animal organ development
• ERBB4 signaling pathway
• intracellular signal transduction
• nervous system development
• signal transduction

Molecular functions

• growth factor activity
• signaling receptor binding

Cellular components

• extracellular region
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• EGF-like domain
• Neuregulin, C-terminal
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Neuregulin
• Neuregulin intracellular region
• Immunoglobulin I-set domain
• Neuregulin 2, N-terminal domain
• Neuregulin 2, Ig-like domain
• NRG2 N-terminal

KeywordsUniProt

• Cell membrane
• Disulfide bond
• EGF-like domain
• Glycoprotein
• Growth factor
• Immunoglobulin domain
• Membrane
• Secreted
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of NRG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ERBB3
• ERBB4