Seroatlas · Human Serome Atlas

NRARP

Notch-regulated ankyrin repeat-containing protein

Also known as: MGC61598, NRARP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6K4
Gene: NRARP
Ensembl: ENSG00000198435
Chromosome: 9
Canonical length: 114 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in Notch signaling pathway. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of canonical Wnt signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>Q7Z6K4|NRARP
     1  MSQAELSTCS APQTQRIFQE AVRKGNTQEL QSLLQNMTNC EFNVNSFGPE GQTALHQSVI
    61  DGNLELVKLL VKFGADIRLA NRDGWSALHI AAFGGHQDIV LYLITKAKYA ASGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRARP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

colon: 45 nTPM
skin: 34 nTPM
esophagus: 31 nTPM
rectum: 29 nTPM
duodenum: 21 nTPM
heart muscle: 18 nTPM

Single-cell type

suprabasal keratinocytes: 381 nCPM
ocular epithelial cells: 178 nCPM
prostatic club cells: 178 nCPM
prostatic hillock cells: 157 nCPM
colonocytes: 152 nCPM
basal keratinocytes: 144 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 26 nTPM
midbrain: 21 nTPM
thalamus: 19 nTPM
medulla oblongata: 19 nTPM
pons: 17 nTPM
spinal cord: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0.21
gnomAD missense Z: 2.33
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NRARP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LEF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRARP as an antibody target. Whether an autoantibody or antibody against NRARP could matter depends on whether native NRARP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRARP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRARP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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