Seroatlas · Human Serome Atlas

NPY6R

Putative neuropeptide Y receptor type 6

Also known as: NPY6R_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99463
Gene
NPY6R
Canonical length
290 aa

OverviewNCBI Gene

No narrative summary is available for NPY6R in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q99463|NPY6R
     1  MEVSLNHPAS NTTSTKNNNS AFFYFESCQP PSPALLLLCI AYTVVLIVGL FGNLSLIIII
    61  FKKQRKAQNF TSILIANLSL SDTLVCVMCI HFTIIYTLMD HWIFGDTMCR LTSYVQSVSI
   121  SVSIFSLVFT AVERYQLIVN PRGWKPSVTH AYWGITLIWL FSLLLSIPFF LSYHLTDEPF
   181  RNLSLPTDLY THQVACVENW PSKKDRLLFT TSLFLLQYFV PLGFILICYL KIVICLRRRN
   241  AKVDKKKENE GRLNENKRIN TMLISIVVTF GACWLPRISS MSSLTGIMRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPY6R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.35

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPY6R as an antibody target. Whether an autoantibody or antibody against NPY6R could matter depends on whether native NPY6R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPY6R is annotated at the cell surface, where native NPY6R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NPY6R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPY6R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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