Seroatlas · Human Serome Atlas

NPY5R

Neuropeptide Y receptor type 5

Also known as: NPY5R_HUMAN, NPYR5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15761
Gene
NPY5R
Ensembl
ENSG00000164129
Chromosome
4
Canonical length
445 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q15761|NPY5R
     1  MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF VSLLGFMGNL
    61  LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT SVLLDQWMFG KVMCHIMPFL
   121  QCVSVLVSTL ILISIAIVRY HMIKHPISNN LTANHGYFLI ATVWTLGFAI CSPLPVFHSL
   181  VELQETFGSA LLSSRYLCVE SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC
   241  GLSNKENRLE ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP
   301  ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL RVKRSVTRIK
   361  KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL
   421  NPILYGFLNN GIKADLVSLI HCLHM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPY5R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
8.3 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 8.3 nTPM
  • adipose tissue: 6.7 nTPM
  • testis: 4.8 nTPM
  • kidney: 4.3 nTPM
  • basal ganglia: 3.8 nTPM
  • salivary gland: 3.5 nTPM

Single-cell type

  • adipocytes: 16 nCPM
  • late primary spermatocytes: 8.2 nCPM
  • brain inhibitory neurons: 7.8 nCPM
  • brain excitatory neurons: 4.1 nCPM
  • other brain neurons: 3.3 nCPM
  • pericytes: 2.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 7.2 nTPM
  • basal ganglia: 5.7 nTPM
  • cerebral cortex: 3.5 nTPM
  • spinal cord: 3.3 nTPM
  • hippocampal formation: 2.6 nTPM
  • white matter: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0.01
gnomAD missense Z
0.73
DepMap mean gene effect
0.18
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPY5R as an antibody target. Whether an autoantibody or antibody against NPY5R could matter depends on whether native NPY5R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPY5R is annotated at the cell surface, where native NPY5R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NPY5R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPY5R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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