Seroatlas · Human Serome Atlas

NPY4R

Neuropeptide Y receptor type 4

Also known as: NPY4R_HUMAN, PP1, PPYR1, Y4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50391
Gene: NPY4R
Ensembl: ENSG00000204174
Chromosome: 10
Canonical length: 375 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>P50391|NPY4R
     1  MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI ETVVGVLGNL
    61  CLMCVTVRQK EKANVTNLLI ANLAFSDFLM CLLCQPLTAV YTIMDYWIFG ETLCKMSAFI
   121  QCMSVTVSIL SLVLVALERH QLIINPTGWK PSISQAYLGI VLIWVIACVL SLPFLANSIL
   181  ENVFHKNHSK ALEFLADKVV CTESWPLAHH RTIYTTFLLL FQYCLPLGFI LVCYARIYRC
   241  LQRQGRVFHK GTYSLRAGHM KQVNVVLVVM VVAFAVLWLP LHVFNSLEDW HHEAIPICHG
   301  NLIFLVCHLL AMASTCVNPF IYGFLNTNFK KEIKALVLTC QQSAPLEESE HLPLSTVHTE
   361  VSKGSLRLSG RSNPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPY4R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

rectum: 5.6 nTPM
colon: 4.6 nTPM
skin: 2.8 nTPM
stomach: 1.8 nTPM
duodenum: 1.4 nTPM
prostate: 1.3 nTPM

Single-cell type

epicardial cells: 2.3 nCPM
colonocytes: 0.1 nCPM
mesothelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 4.8 nTPM
thalamus: 2.7 nTPM
medulla oblongata: 1.7 nTPM
cerebellum: 1.5 nTPM
midbrain: 1.5 nTPM
pons: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: 0.14

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPY4R as an antibody target. Whether an autoantibody or antibody against NPY4R could matter depends on whether native NPY4R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPY4R is annotated at the cell surface, where native NPY4R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NPY4R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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