Seroatlas · Human Serome Atlas

NPY1R

Neuropeptide Y receptor type 1

Also known as: NPY1R_HUMAN, NPYR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P25929
Gene
NPY1R
Ensembl
ENSG00000164128
Chromosome
4
Canonical length
384 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>P25929|NPY1R
     1  MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV IILGVSGNLA
    61  LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY TLMDHWVFGE AMCKLNPFVQ
   121  CVSITVSIFS LVLIAVERHQ LIINPRGWRP NNRHAYVGIA VIWVLAVASS LPFLIYQVMT
   181  DEPFQNVTLD AYKDKYVCFD QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR
   241  RNNMMDKMRD NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL
   301  LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI AMSTMHTDVS
   361  KTSLKQASPV AFKKINNNDD NEKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPY1R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 113 nTPM
  • blood vessel: 45 nTPM
  • breast: 30 nTPM
  • kidney: 30 nTPM
  • adrenal gland: 29 nTPM
  • adipose tissue: 29 nTPM

Single-cell type

  • adipocytes: 176 nCPM
  • hepatic stellate cells: 97 nCPM
  • distal convoluted tubule cells: 92 nCPM
  • pancreatic duct cells: 75 nCPM
  • brain inhibitory neurons: 64 nCPM
  • vascular smooth muscle cells: 64 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • hypothalamus: 56 nTPM
  • cerebral cortex: 40 nTPM
  • basal ganglia: 36 nTPM
  • white matter: 32 nTPM
  • hippocampal formation: 25 nTPM
  • spinal cord: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.04
gnomAD missense Z
1.78
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPY1R as an antibody target. Whether an autoantibody or antibody against NPY1R could matter depends on whether native NPY1R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPY1R is annotated at the cell surface, where native NPY1R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NPY1R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPY1R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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