Seroatlas · Human Serome Atlas

NPIPB9

Nuclear pore complex-interacting protein family member B9

Also known as: NPIB9_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: F8W1W9
Gene: NPIPB9
Canonical length: 432 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for NPIPB9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>F8W1W9|NPIPB9
     1  MVKLSIVLTP QFLSHDQSQF TKELQQHVKS VTCPCEYLRK VINSLAVYRH RETDFGVGVR
    61  DHPGQHGKTP SPQKLDNLII IIIGFLRRYT FNILFCTSCL CVSFLKTIFW SRNGHDGSMD
   121  VQQRAWRSNR SRQKGLRSIC MHTKKRVSSF RGNKIGLKDV ITLRRHVETK VRAKIRKRKV
   181  TTKINRHDKI NGKRKTARKQ KMFQRAQELR RRAEDYHKCK IPPSARKPLC NWVRMAAAEH
   241  RHSSGLPYWL YLTAETLKNR MGRQPPPPTQ QHSITDNSLS LKTPPECLLT PLPPSVDDNI
   301  KECPLAPLPP SPLPPSVDDN LKECLFVPLP PSPLPPSVDD NLKECLFVPL PPSPLPPSVD
   361  DNLKTPPLAT QEAEVEKPPK PKRWRVDEVE QSPKPKRQRE AEAQQLPKPK RRRLSKLRTR
   421  HCTQAWAIRI NP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

testis: 2.6 nTPM
ovary: 1.6 nTPM
cerebellum: 1.5 nTPM
skin: 1.3 nTPM
cerebral cortex: 1 nTPM
spinal cord: 1 nTPM

Single-cell type

early spermatids: 4.4 nCPM
medullary thymic epithelial cells: 2.4 nCPM
retinal horizontal cells: 2 nCPM
late spermatids: 1.5 nCPM
early primary spermatocytes: 1.3 nCPM
respiratory ciliated cells: 1.2 nCPM

Immune cell

memory B-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 5 nTPM
pons: 4 nTPM
white matter: 4 nTPM
midbrain: 3.7 nTPM
hypothalamus: 3.5 nTPM
thalamus: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0.11
gnomAD missense Z: -0.13

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB9 as an antibody target. Whether an autoantibody or antibody against NPIPB9 could matter depends on whether native NPIPB9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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