Seroatlas · Human Serome Atlas

NPIPB8

Nuclear pore complex-interacting protein family member B8

Also known as: NPIB8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: E9PQR5
Gene: NPIPB8
Ensembl: ENSG00000255524
Chromosome: 16
Canonical length: 432 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for NPIPB8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>E9PQR5|NPIPB8
     1  MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINSLAVYRH RETDFGVGVR
    61  DHPGQHGKTP SPQKLDNLII IIIGFLRCYT FNILFCTSCL CVSFLKTIFW SRNGHDGSMD
   121  VQQRAWRSNR SRQKGLRSIC MHTKKRVSSF RGNKIGLKDV ITLRRHVETK VRAKIRKRKV
   181  TTKINRHDKI NGKRKTARKQ KMFQRAQELR RRAEDYHKCK IPPSARKPLC NWVRMAAAEH
   241  RHSSGLPYWL YLTAETLKNR MGRQPPPPTQ QHSITDNSLS LKTPPECLLT PLPPSVDDNI
   301  KECPLAPLPP SPLPPSVDDN LKECLFVPLP PSPLPPSVDD NLKECLFVPL PPSPLPPSVD
   361  DNLKTPPLAT QEAEVEKPPK PKRWRVDEVE QSPKPKRQRE AEAQQLPKPK RRRLSKLRTR
   421  HCTQAWAIRI NP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

testis: 17 nTPM
salivary gland: 2 nTPM
cerebellum: 1.9 nTPM
colon: 1.7 nTPM
liver: 1.7 nTPM
pituitary gland: 1.7 nTPM

Single-cell type

early spermatids: 28 nCPM
late spermatids: 10 nCPM
late primary spermatocytes: 4.3 nCPM
thymocytes: 2.5 nCPM
epicardial cells: 2.3 nCPM
melanocytes: 2 nCPM

Immune cell

memory B-cell: 0.6 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 1.9 nTPM
cerebral cortex: 1.7 nTPM
pons: 1.6 nTPM
basal ganglia: 1.5 nTPM
hypothalamus: 1.5 nTPM
cerebellum: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.87

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB8 as an antibody target. Whether an autoantibody or antibody against NPIPB8 could matter depends on whether native NPIPB8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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