NPIPB7
Nuclear pore complex-interacting protein family member B7
Also known as: LOC440350, NPIB7_HUMAN, NPIPL1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75200
- Gene
- NPIPB7
- Ensembl
- ENSG00000233232
- Chromosome
- 16
- Canonical length
- 414 aa
- Protein class
- Predicted membrane proteins, Predicted secreted proteins
- Subcellular location
- Nucleoplasm
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
414 residues, UniProt reviewed canonical sequence.
>O75200|NPIPB7
1 MRLRFWLLIW LLLGFISHQP TPVINSLAVY RHRETDFGVG VRDHPGQHGK TPSPQKLDNL
61 IIIIIGFLRR YTFNVLFCTS CLCVSFLKTI FWSRNGHDGS MDVQQRAWRS NRSRQKGLRS
121 ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINRHD KINGKRKTAR
181 KQKMFQRAQE LRRRAEDYHK CKIPPSARKP LCNWVRMAAA EHCHSSGLPY WLYLTAETLK
241 NRMGRQPPPP TQQHSITDNS LSLKTPPECL LTPLPPSVDD NIKECPLAPL PPSPLPPSVD
301 DNLKECLFVP LPPSPLPPSV DDNLKECLFV PLPPSPLPPS VDDNLKTPPL ATQEAEVEKP
361 PKPKRWRVDE VEQSPKPKRQ REAEAQQLPK PKRRRLSKLR TRHCTQAWAI RINPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NPIPB7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- testis: 27 nTPM
- skeletal muscle: 5.7 nTPM
- skin: 3.8 nTPM
- retina: 3.6 nTPM
- bone marrow: 3.2 nTPM
- cerebellum: 2.9 nTPM
Single-cell type
- early spermatids: 28 nCPM
- late spermatids: 9.5 nCPM
- late primary spermatocytes: 6.3 nCPM
- sertoli cells: 0.3 nCPM
- epididymal basal cells: 0.2 nCPM
- goblet cells: 0.2 nCPM
Immune cell
- memory B-cell: 0.3 nTPM
- naive B-cell: 0.1 nTPM
- neutrophil: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 45 nTPM
- cerebellum: 37 nTPM
- amygdala: 32 nTPM
- hypothalamus: 32 nTPM
- hippocampal formation: 29 nTPM
- thalamus: 28 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.93
- gnomAD pLI
- 0.02
- gnomAD missense Z
- -0.35
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NPIPB7 as an antibody target. Whether an autoantibody or antibody against NPIPB7 could matter depends on whether native NPIPB7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NPIPB7 is annotated as secreted, so native NPIPB7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label NPIPB7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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