Seroatlas · Human Serome Atlas

NPIPB6

Nuclear pore complex-interacting protein family member B6

Also known as: NPIB6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: E9PJ23
Gene: NPIPB6
Ensembl: ENSG00000198156
Chromosome: 16
Canonical length: 425 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for NPIPB6 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>E9PJ23|NPIPB6
     1  MVKLSIVLTP QFLSHDQSQL TKELQQHVKS VTCPCEYLRK VINSLAVYRH RETDFGVGVR
    61  DHPGQHGKTP SPQKLDNLII IIIGFLRRYT FNILFCTSCL CVSFLKTIFW SRNGHDGSMD
   121  VQQRAWRSNR SRQKGLRSIC MHTKKRVSSF RGNKIGLKDV ITLRRHVETK VRAKIRKRKV
   181  TTKINRHDKI NGKRKTARKQ KMFQRAQELR RRAEDYHKCK IPPSARKPLC NWVRMVAAEH
   241  RHSSGLPYWP YLTAETLKNR MGRQPPPPTQ QHSITDNSLS LKTPTECLLT PLPPSVDDNI
   301  KECPLAPLPP SPLPPSVDDN LKECLFVPLP PSPLPPSVDD NLKTPPLATQ EAEVEKPPKP
   361  KRWRVDEVEQ SPKPKRRRVD EVEQSPKPKR QREAEAQQLP KPKRRRLSKL RTRHCTQAWA
   421  IRINP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

testis: 36 nTPM
cerebellum: 3.8 nTPM
ovary: 3.1 nTPM
basal ganglia: 2.6 nTPM
fallopian tube: 2.5 nTPM
spinal cord: 2.5 nTPM

Single-cell type

early spermatids: 287 nCPM
late spermatids: 198 nCPM
late primary spermatocytes: 130 nCPM
respiratory ciliated cells: 3.8 nCPM
epididymal basal cells: 3.4 nCPM
epididymal efferent duct ciliated cells: 2.9 nCPM

Immune cell

memory B-cell: 0.7 nTPM
naive B-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM

Brain region

white matter: 4.3 nTPM
cerebellum: 2.7 nTPM
hypothalamus: 2.7 nTPM
pons: 2.7 nTPM
basal ganglia: 2.4 nTPM
cerebral cortex: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -1.02

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB6 as an antibody target. Whether an autoantibody or antibody against NPIPB6 could matter depends on whether native NPIPB6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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