Seroatlas · Human Serome Atlas

NPIPB5

Nuclear pore complex-interacting protein family member B5

Also known as: NPIB5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MRT5
Gene: NPIPB5
Ensembl: ENSG00000243716
Chromosome: 16
Canonical length: 1133 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1133 residues, UniProt reviewed canonical sequence.

>A8MRT5|NPIPB5
     1  MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
    61  LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
   121  ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
   181  KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSITDNS LSLKTPPECL LTPLPPSADD NLKTPPECVL TPLPPSADDN
   301  LKTPPECVLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL PPSALPSAPP
   361  SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
   421  PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL
   481  PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT ALPPSADDNI KTPAERLRGP
   541  LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAFHPQ RMISRHLPSV SSLPFHPQLH
   601  PQQMIISRYL LSVCGFRFHH QPMIISRHLP SVSSLPFHPQ LHPQQMIISR HLPSVCGGRF
   661  HPERMIISRH LPSVSSLPFH PQLHPQQMII SRHLPSVCGG RFHPQQMIIS RHLPSVSSLP
   721  FHPQLHPQQM IISRHLPSVC GGRFHPQRMI ISRHLPSVSS LPFHPQLHPQ QMIISRHLPS
   781  VCGGRFHPQQ MIISRHLPSV SSLPFHPQLH PQQMIISRHL PSVCGGRFHP QRMIISRHLP
   841  SVSSLPFHPQ LHPQQMIISR HLPSVCGERL RGPLPPSADD NLKTPSERQL TPLPPSAPPS
   901  ADDNIKTPAE RLRGPLPPSA DDNLKTPSER QLTPLPPSAP PSADDNIKTP AERLRGPLPP
   961  SADDNLKTPS ERQLTPLPPS APPSADDNIK TPAERLRGPL PPSADDNLKT PPLATQEAEA
  1021  EKPRKPKRQR AAEMEPPPEP KRRRVGDVEP SRKPKRRRAA DVEPSSPEPK RRRVGDVEPS
  1081  RKPKRRRAAD VEPSSPEPKR RRVGDVEPSR KPKRRRAADV EPSLPEPKRR RLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 139 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 139 nTPM
skin: 100 nTPM
small intestine: 86 nTPM
thyroid gland: 86 nTPM
retina: 85 nTPM
skeletal muscle: 81 nTPM

Single-cell type

proximal tubule cells: 103 nCPM
renal connecting tubule cells: 82 nCPM
distal convoluted tubule cells: 71 nCPM
podocytes: 71 nCPM
renal collecting duct intercalated cells: 63 nCPM
loop of henle epithelial cells: 55 nCPM

Immune cell

naive B-cell: 4.6 nTPM
basophil: 4 nTPM
memory B-cell: 2.8 nTPM
plasmacytoid DC: 2.6 nTPM
gdT-cell: 2.3 nTPM
neutrophil: 2.3 nTPM

Brain region

cerebellum: 265 nTPM
cerebral cortex: 261 nTPM
amygdala: 247 nTPM
thalamus: 224 nTPM
midbrain: 217 nTPM
white matter: 215 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.15

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB5 as an antibody target. Whether an autoantibody or antibody against NPIPB5 could matter depends on whether native NPIPB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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