Seroatlas · Human Serome Atlas

NPIPB4

Nuclear pore complex-interacting protein family member B4

Also known as: NPIB4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JG80
Gene: NPIPB4
Ensembl: ENSG00000185864
Chromosome: 16
Canonical length: 1138 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1138 residues, UniProt reviewed canonical sequence.

>C9JG80|NPIPB4
     1  MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
    61  LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
   121  ICMHTKKRVS SFRGNKIVLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
   181  KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSITDNS LSLKTPPECL LTPLPPSADD NLKTPPECVL TPLPPSADDN
   301  LKTPPECVLT PLPPSADDNL KTPPECLLTP LPPSADDKLK TPPECLLTPL PPSALPSAPP
   361  SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
   421  PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL
   481  PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER
   541  LRGPLPPSAD DNLKTPSERQ LTPLPPSAPP SADDNIKTPA ERLRGPLPPS ADDNLKTPSE
   601  RQLTPLPPSA PPSADDNIKT PAFHPQRMII SRHLPSVSSL PFHPQLHPQQ MIISRYLLSV
   661  CGFRFHHQPM IISRHLPSVS SLPFHPQLHP QQMIISRHLP SVCGGRFHPQ RMIISRHLPS
   721  VSSLPFHPQL HPQQMIISRH LPSVCGGRFH PQRMIISRHL PSVSSLPFHP QLHPQQMIIS
   781  RHLPSVCGGR FHPQRMIISR HLPSVSSLPF HPQLHPQQMI ISRHLPSVCG GRFHPQRMII
   841  SRHLPSVSSL PFHPQLHPQQ MIISRHLPSV CGERLRGPLP PSADDNLKTP SERQLTPLPP
   901  SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAERLR
   961  GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD DNLKTPPLAT
  1021  QEAEAEKPRK PKRQRAAEME PPPEPKRRRV GDVEPSRKPK RRRAADVEPS SPEPKRRRVG
  1081  DVEPSRKPKR RRAADVEPSS PEPKRRRVGD VEPSRKPKRR RAADVEPSLP EPKRRRLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

spleen: 39 nTPM
cerebellum: 38 nTPM
skin: 34 nTPM
small intestine: 34 nTPM
thyroid gland: 30 nTPM
liver: 29 nTPM

Single-cell type

early spermatids: 202 nCPM
proximal tubule cells: 44 nCPM
renal connecting tubule cells: 34 nCPM
distal convoluted tubule cells: 33 nCPM
late spermatids: 30 nCPM
podocytes: 26 nCPM

Immune cell

naive B-cell: 0.8 nTPM
gdT-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
neutrophil: 0.4 nTPM
basophil: 0.3 nTPM
memory B-cell: 0.3 nTPM

Brain region

cerebral cortex: 106 nTPM
amygdala: 100 nTPM
cerebellum: 99 nTPM
thalamus: 93 nTPM
hippocampal formation: 88 nTPM
pons: 86 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0.18
gnomAD missense Z: -0.45

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB4 as an antibody target. Whether an autoantibody or antibody against NPIPB4 could matter depends on whether native NPIPB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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