Seroatlas · Human Serome Atlas

NPIPB3

Nuclear pore complex-interacting protein family member B3

Also known as: KIAA0220, NPIB3_HUMAN, NPIPL3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92617
Gene
NPIPB3
Ensembl
ENSG00000169246
Chromosome
16
Canonical length
1050 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be located in nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1050 residues, UniProt reviewed canonical sequence.

>Q92617|NPIPB3
     1  MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
    61  LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
   121  ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
   181  KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSITDNS LSLKTPPECL LTPLPPSADD NLKTPPECVL TPLPPSADDN
   301  LKTPPECVLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL PPSALPSAPP
   361  SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
   421  PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL
   481  PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT ALPPSADDNI KTPAERLRGP
   541  LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAFHPQ RMIISRHLPS VSSLPFHPQL
   601  HPQQMIISRH LPSVCGGRFH PQQMIISRHL PSVSSLPFHP QLHPQQMIIS RHLPSVCGGR
   661  FHPQRMIISR HLPSVSSLPF HPQLHPQQMI ISRHLPSVCG GRFHPQQMII SRHLPSVSSL
   721  PFHPQLHPQQ MIISRHLPSV CGGRFHPQRM IISRHLPSVS SLPFHPQLHP QQMIISRHLP
   781  SVCGERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAERLR GPLPPSADDN
   841  LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD DNLKTPSERQ LTPLPPSAPP
   901  SADDNIKTPA ERLRGPLPPS ADDNLKTPPL ATQEAEAEKP RKPKRQRAAE MEPPPEPKRR
   961  RVGDVEPSRK PKRRRAADVE PSSPEPKRRR VGDVEPSRKP KRRRAADVEP SSPEPKRRRV
  1021  GDVEPSRKPK RRRAADVEPS LPEPKRRRLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
220 nTPM

Expression across tissuesHPA

Tissue

  • skin: 220 nTPM
  • bone marrow: 181 nTPM
  • cerebellum: 127 nTPM
  • spleen: 122 nTPM
  • skeletal muscle: 112 nTPM
  • lymph node: 109 nTPM

Single-cell type

  • proximal tubule cells: 12 nCPM
  • distal convoluted tubule cells: 8.9 nCPM
  • renal connecting tubule cells: 8.5 nCPM
  • choroid plexus epithelial cells: 7.3 nCPM
  • renal collecting duct intercalated cells: 5.5 nCPM
  • loop of henle epithelial cells: 5.2 nCPM

Immune cell

  • basophil: 33 nTPM
  • NK-cell: 18 nTPM
  • neutrophil: 12 nTPM
  • naive B-cell: 12 nTPM
  • plasmacytoid DC: 9.9 nTPM
  • memory B-cell: 7.4 nTPM

Brain region

  • cerebral cortex: 382 nTPM
  • midbrain: 274 nTPM
  • hypothalamus: 258 nTPM
  • thalamus: 237 nTPM
  • amygdala: 235 nTPM
  • medulla oblongata: 233 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
gnomAD missense Z
-0.68

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB3 as an antibody target. Whether an autoantibody or antibody against NPIPB3 could matter depends on whether native NPIPB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPIPB3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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