Seroatlas · Human Serome Atlas

NPIPB2

Nuclear pore complex-interacting protein family member B2

Also known as: NPIB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NJ64
Gene
NPIPB2
Ensembl
ENSG00000234719
Chromosome
16
Canonical length
397 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>A6NJ64|NPIPB2
     1  MFCCLGYEWL SGGCKTWHSA WVINTLADHH HRGTDFGGSP WLRIIIAFPR SYKVVLTLWT
    61  VYLWLSFLKT IFQSENGHDV STDVQQRARR SNRRRQEGLR SICMHTKKRV SSFPGNKIGL
   121  KDVITLRRHV ETKGRAKIRK MKVTTKINHH DKINGKRKTA KKQKLSVKEC EHAEKERQVS
   181  EAEENGKLDM KEIHTYMKMF QRAQELRRRA EDYHKCKIPP SARKALCNWV RMAAAEHRHS
   241  SGLPYWPYLT AETLKNRMGH QPPPPTQQHS ITDNSLSLKT PPECLLTPLP PSADDNLKTP
   301  PECLLTPLPP SAPPSADDNL KTPPLATQEA EAEKPPKPKR WRAAEMESPP EPKRRRAAEV
   361  ESPPEPKRRR AAEVEPSSPE PKRRRLSKLR TGHCTQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • skin: 12 nTPM
  • testis: 8.9 nTPM
  • skeletal muscle: 8.6 nTPM
  • epididymis: 6.9 nTPM
  • thymus: 6.8 nTPM
  • bone marrow: 6.4 nTPM

Single-cell type

  • early spermatids: 139 nCPM
  • plasma cells: 40 nCPM
  • late primary spermatocytes: 24 nCPM
  • choroid plexus epithelial cells: 17 nCPM
  • late spermatids: 16 nCPM
  • renal collecting duct principal cells: 15 nCPM

Immune cell

  • NK-cell: 1.5 nTPM
  • plasmacytoid DC: 1 nTPM
  • classical monocyte: 0.9 nTPM
  • memory B-cell: 0.9 nTPM
  • naive CD4 T-cell: 0.9 nTPM
  • naive B-cell: 0.8 nTPM

Brain region

  • cerebellum: 49 nTPM
  • cerebral cortex: 49 nTPM
  • amygdala: 48 nTPM
  • thalamus: 43 nTPM
  • basal ganglia: 43 nTPM
  • hippocampal formation: 43 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB2 as an antibody target. Whether an autoantibody or antibody against NPIPB2 could matter depends on whether native NPIPB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPIPB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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