Seroatlas · Human Serome Atlas

NPIPB15

Nuclear pore complex-interacting protein family member B15

Also known as: LOC440348, NPB15_HUMAN, NPIPL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NHN6
Gene: NPIPB15
Ensembl: ENSG00000196436
Chromosome: 16
Canonical length: 443 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>A6NHN6|NPIPB15
     1  MRLRFWLLIW LLLGFISHQP TPVINSLAVY RHRETDFGVG VRDHPGQHGK TPSPQKLDNL
    61  IIIIIGFLRR DTFTILFCTS YLCVSFLKTI FWSRNGHDGS TDVQQRAWRS NRSRQKGLRS
   121  ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINRHD KINGKRKTAR
   181  KQKMFQRAQE LRRRAEDYHK CKIPPSARKP LCNWVRMAAA EHRHSSGLPC WPYLTAEALK
   241  NRMGRQPPPP TQQHSITDNS LSLKTPPECL LHPLPPSVDD NIKECPLAPL PPSVDDNLKE
   301  YLLVPLPPSP LPPSVDDNLK DCLFVPLPPS PLPPSVDDNL KTPPLATQEA EAEKPPKPKR
   361  WRVDEVEQSP KPKRRRADEV EQSPKPKRQR EAEAQQLPKP KRRRLSKLRT RHCTQAWAIR
   421  INPWVEKKKK IKKQNKTHAP KTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

testis: 45 nTPM
liver: 31 nTPM
salivary gland: 21 nTPM
prostate: 20 nTPM
pancreas: 16 nTPM
pituitary gland: 16 nTPM

Single-cell type

late spermatids: 329 nCPM
early spermatids: 238 nCPM
late primary spermatocytes: 156 nCPM
goblet cells: 57 nCPM
mucous neck cells: 33 nCPM
paneth cells: 27 nCPM

Immune cell

memory B-cell: 0.9 nTPM
naive B-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 9.8 nTPM
cerebellum: 9 nTPM
amygdala: 8.7 nTPM
hypothalamus: 8.1 nTPM
basal ganglia: 7.9 nTPM
thalamus: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -1.18

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB15 as an antibody target. Whether an autoantibody or antibody against NPIPB15 could matter depends on whether native NPIPB15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB15 is annotated as secreted, so native NPIPB15 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NPIPB15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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