Seroatlas · Human Serome Atlas

NPIPB13

Nuclear pore complex-interacting protein family member B13

Also known as: NPB13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJU9
Gene: NPIPB13
Ensembl: ENSG00000198064
Chromosome: 16
Canonical length: 1138 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1138 residues, UniProt reviewed canonical sequence.

>A6NJU9|NPIPB13
     1  MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
    61  LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
   121  ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
   181  KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSITDNS LSLKTPPECV LTPLPPSADD NLKTPPECVL TPLPPSADDN
   301  LKTPPECLLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL PPSAPPSAPP
   361  SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
   421  PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL
   481  PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER
   541  LRGPLPPSAD DNLKTPSERQ LTPLPPSAPP SADDNIKTPA FHPQRMIISR HLPSVSSLPF
   601  HPQLHSQQMI ISRYLLSVCG FRFHHQPMII SRHLPSVSSL PFHPQLHPQQ MIISRHLPSV
   661  CGGRFHPQRM IISRHLPSVS SLPFHPQLHP QQMIISRHLP SVCGGRFHPQ RMIISRHLPS
   721  VSSLPFHPQL HPQQMIISRH LPSVCGERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA
   781  DDNIKTPAER LRRPLPPSAD DNLKTPSERQ LTPLPPSAPP SADDNIKTPA ERLRGPLPPS
   841  ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP PSADDNLKTP SERQLTPLPP
   901  SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAERLR
   961  GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD DNLKTPPLAT
  1021  QEAEAEKPRK PKRQRAAEME PPPEPKRRRV GDVEPSRKPK RRRAADVEPS SPKPKRRRVG
  1081  DVEPSRKPKR RRAADVEPSS PEPKRRRVGD VEPSRKPKRR RAADVEPSSP EPKRRRLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

skin: 39 nTPM
bone marrow: 32 nTPM
epididymis: 30 nTPM
retina: 28 nTPM
skeletal muscle: 21 nTPM
lymph node: 19 nTPM

Single-cell type

proximal tubule cells: 24 nCPM
renal connecting tubule cells: 21 nCPM
distal convoluted tubule cells: 21 nCPM
renal collecting duct intercalated cells: 18 nCPM
loop of henle epithelial cells: 16 nCPM
podocytes: 15 nCPM

Immune cell

basophil: 7.9 nTPM
NK-cell: 6.6 nTPM
neutrophil: 5.6 nTPM
naive B-cell: 3.4 nTPM
plasmacytoid DC: 3.3 nTPM
classical monocyte: 2.6 nTPM

Brain region

cerebral cortex: 241 nTPM
amygdala: 219 nTPM
thalamus: 204 nTPM
midbrain: 203 nTPM
cerebellum: 199 nTPM
medulla oblongata: 190 nTPM

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB13 as an antibody target. Whether an autoantibody or antibody against NPIPB13 could matter depends on whether native NPIPB13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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