Seroatlas · Human Serome Atlas

NPIPB12

Nuclear pore complex-interacting protein family member B12

Also known as: NPB12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: F8W0I5
Gene: NPIPB12
Ensembl: ENSG00000169203
Chromosome: 16
Canonical length: 928 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

928 residues, UniProt reviewed canonical sequence.

>F8W0I5|NPIPB12
     1  MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
    61  LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
   121  ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
   181  KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSITDNS LSLKTPPECV LTPLPPSADD NLKTPPECVL TPLPPSADDN
   301  LKTPPECLLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL PPSAPPSAPP
   361  SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
   421  PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAFHPQRM IISRHLPSVS SLPFHPQLHS
   481  QQMIISRYLL SVCGFRFHHQ PMIISRHLPS VSSLPFHPQL HPQQMIISRH LPSVCGGRFH
   541  PQRMIISRHL PSVSSLPFHP QLHPQQMIIS RHLPSVCGGR FHPQRMIISR HLPSVSSLPF
   601  HPQLHPQQMI ISRHLPSVCG GRFHPQRMII SRHLPSVSSL PFHPQLHPQQ MIISRHLPSV
   661  CGERLRGPLP PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK
   721  TPSERQLTPL PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA
   781  DDNIKTPAER LRGPLPPSAD DNLKTPPLAT QEAEAEKPRK PKRQRAAEME PPPEPKRRRV
   841  GDVEPSRKPK RRRAADVEPS SPEPKRRRVG DVEPSRKPKR RRAADVEPSS PEPKRRRVGD
   901  VEPSRKPKRR RAADVEPSLP EPKRRRLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 14 nTPM
liver: 14 nTPM
spleen: 12 nTPM
small intestine: 11 nTPM
thyroid gland: 11 nTPM
cerebral cortex: 9.3 nTPM

Single-cell type

proximal tubule cells: 4.2 nCPM
distal convoluted tubule cells: 3.9 nCPM
renal connecting tubule cells: 2.9 nCPM
renal collecting duct intercalated cells: 2.8 nCPM
loop of henle epithelial cells: 2.5 nCPM
papillary tip epithelial cells: 2.2 nCPM

Immune cell

NK-cell: 1.1 nTPM
basophil: 0.7 nTPM
neutrophil: 0.6 nTPM
gdT-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM

Brain region

cerebral cortex: 31 nTPM
cerebellum: 11 nTPM
thalamus: 10 nTPM
white matter: 7.3 nTPM
pons: 6.3 nTPM
hypothalamus: 5.8 nTPM

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB12 as an antibody target. Whether an autoantibody or antibody against NPIPB12 could matter depends on whether native NPIPB12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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