Seroatlas · Human Serome Atlas

NPIPB11

Nuclear pore complex-interacting protein family member B11

Also known as: NPB11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: E5RHQ5
Gene: NPIPB11
Ensembl: ENSG00000254206
Chromosome: 16
Canonical length: 1161 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to act upstream of or within prevention of polyspermy. Predicted to be located in external side of plasma membrane and sperm head plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1161 residues, UniProt reviewed canonical sequence.

>E5RHQ5|NPIPB11
     1  MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
    61  LHIIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
   121  ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINRHD KINGKRKTAR
   181  KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHCITDNS LSLKTPLECL LTPLPPSADD NLKTPPECLL TPLPPSADDN
   301  LKTPPECLLT PLPPSAPPSA PPSADDNLKT RAECLLHPLP PSADDNLKTP SERQLTPLPP
   361  SAPPSADDNI KTTAERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAEHLR
   421  GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD DNLKTPSERQ
   481  LTPLPPSAPP SADDNIKTPA EHLRGPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT
   541  TAEHLRGPLP PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAEHLQFR FHPQRMIISR
   601  DLPSVSSLPF HPQLHPQQMI ISRYLLSICG FRFHRQRMII SRHLPSVSSL PFHPQLHPQQ
   661  MIISRHLPSV CGGRFHPQPM IISRHLPSVS SLPFHPQLHP QQMIISRHLP SVCGGRFHPQ
   721  PMIISRHLPS VSSLPFHPQL HPQQMIISRH LPSVCGGRFH PQPMIISRHL PSVSSLPFHP
   781  QLHPQQMIIS RHLPSVCGGR FHPQPMIISR HLPSVSSLPF HPQLHPQQMI ISRHLPSVCG
   841  GRFHPQPMII SRHLPSVSSL PFHPQLHPQQ MIISRHLPSV CGERLWVPLP PSADDNLKTP
   901  SKRQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSKRQLTPL PPSAPPSADD
   961  NIKTPAERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD
  1021  DNLKTPSERQ LTPLPPSAPT SADDNIKTPA ERLRGPLPPS ADDNLKTPPL ATQEAEAEKP
  1081  RKPKRQRAAE MEPPPEPKRR RVGDVEPSRK PKRRRAADVE PSSPEPKRRR VGDVEPSRKP
  1141  KRRRAADVEP SSPEPKRRRL S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPB11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

skin: 7 nTPM
cerebellum: 5.1 nTPM
bone marrow: 4.7 nTPM
skeletal muscle: 4.6 nTPM
lymph node: 4.5 nTPM
retina: 4.4 nTPM

Single-cell type

cardiomyocytes: 129 nCPM
retinal pigment epithelial cells: 47 nCPM
retinal horizontal cells: 42 nCPM
epicardial cells: 34 nCPM
early spermatids: 16 nCPM
adipocytes: 13 nCPM

Immune cell

basophil: 0.5 nTPM
naive B-cell: 0.4 nTPM
neutrophil: 0.3 nTPM
memory B-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

cerebral cortex: 14 nTPM
cerebellum: 11 nTPM
choroid plexus: 9.5 nTPM
thalamus: 9.3 nTPM
amygdala: 9.1 nTPM
hypothalamus: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0.01
gnomAD missense Z: -2.15

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPB11 as an antibody target. Whether an autoantibody or antibody against NPIPB11 could matter depends on whether native NPIPB11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPB11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPB11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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