Seroatlas · Human Serome Atlas

NPIPA9

Nuclear pore complex-interacting protein family member A9

Also known as: NPIA9_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0B4J1W7
Gene: NPIPA9
Canonical length: 369 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for NPIPA9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>A0A0B4J1W7|NPIPA9
     1  MFCCLGYEWL SGGCKTWHSA WVINTLADHR HRGTDFGGSP WLLIITVFLR SYKFAISLCT
    61  SYLCVSFLKT IFPSQNGHDG STDVQQRARR SNCRRQEGIK IVLEDIFTLW RQVETKVRAK
   121  IRKMKVTTKV NRHDKINGKR KTAKEHLRKL SMKEREHGEK ERQVSEAEEN GKLDMKEIHT
   181  YMEMFQRAQA LRRRAEDYYR CKITPSARKP LCNRVRMAAV EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSIIDNS LSLKTPSECV LYPLPPSADD NLKTPPECLL TPLPPSALPS
   301  ADDNLKTPAE CLLYPLPPSA DDNLKTPPEC LLTPLPPSAP PSADDNLKTP PECVCSLPFH
   361  PQRMIISRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPA9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 546 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 546 nTPM
pituitary gland: 240 nTPM
cerebral cortex: 219 nTPM
hippocampal formation: 188 nTPM
ovary: 171 nTPM
colon: 154 nTPM

Single-cell type

retinal ganglion cells: 3.9 nCPM
myonuclei: 3.4 nCPM
myosatellite cells: 3.3 nCPM
leydig cells: 2.5 nCPM
respiratory ionocytes: 2.5 nCPM
megakaryocyte progenitors: 2.2 nCPM

Immune cell

memory B-cell: 1.3 nTPM
gdT-cell: 0.8 nTPM
memory CD8 T-cell: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM
naive CD4 T-cell: 0.4 nTPM
T-reg: 0.4 nTPM

Brain region

cerebellum: 211 nTPM
cerebral cortex: 169 nTPM
pons: 113 nTPM
white matter: 102 nTPM
medulla oblongata: 101 nTPM
hippocampal formation: 97 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPA9 as an antibody target. Whether an autoantibody or antibody against NPIPA9 could matter depends on whether native NPIPA9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPA9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPA9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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