Seroatlas · Human Serome Atlas

NPIPA8

Nuclear pore complex-interacting protein family member A8

Also known as: LCR16a9, NPIA8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DM63
Gene
NPIPA8
Ensembl
ENSG00000214940
Chromosome
16
Canonical length
369 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for NPIPA8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>P0DM63|NPIPA8
     1  MFCCLGYEWL SGGCTTWHSA WVINTLADHR HRGTDFGGSP WLLIITVFLR SYKFAISLCT
    61  SYLCVSFLKT IFPSQNGHDG STDVQQRARR SNRRRQEGIK IVLEDIFTLW RQVETKVRAK
   121  IRKMKVTTKV NRHDKINGKR KTAKEHLRKL SMKEREHREE ERQVSEAEEN GKLDMKEIHT
   181  YMEMFQRAQA LRRRAEDYYR CKITPSARKP LCNRVRMAAV EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSIIDNS LSLKTPSECV LYPLPPSADD NLKTPPECLL TPLPPSALPS
   301  ADDNLKTPAE CLLYPLPPSA DDNLKTPPEC LLTPLPPSAP PSADDNLKTP PECVCSLPFH
   361  PQRMIISRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
96 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 96 nTPM
  • pituitary gland: 33 nTPM
  • hippocampal formation: 30 nTPM
  • cerebral cortex: 28 nTPM
  • colon: 24 nTPM
  • hypothalamus: 22 nTPM

Single-cell type

  • papillary tip epithelial cells: 2.9 nCPM
  • loop of henle epithelial cells: 2.3 nCPM
  • podocytes: 2.3 nCPM
  • renal connecting tubule cells: 2.1 nCPM
  • renal collecting duct principal cells: 1.9 nCPM
  • proximal tubule cells: 1.7 nCPM

Immune cell

  • memory B-cell: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • cerebellum: 14 nTPM
  • cerebral cortex: 12 nTPM
  • pons: 8.6 nTPM
  • hypothalamus: 7.9 nTPM
  • hippocampal formation: 7.3 nTPM
  • medulla oblongata: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0.06
gnomAD missense Z
-1.4

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPA8 as an antibody target. Whether an autoantibody or antibody against NPIPA8 could matter depends on whether native NPIPA8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPA8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPA8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPIPA8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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