Seroatlas · Human Serome Atlas

NPIPA6

Nuclear pore complex-interacting protein family member A6

Also known as: NPIA6_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DXC3
Gene: NPIPA6
Canonical length: 369 aa

OverviewNCBI Gene

No narrative summary is available for NPIPA6 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>P0DXC3|NPIPA6
     1  MFCCLGYEWL SGGCKTWHSA WVINTLADHR HRGTDFGGSP WLLIITVFLR SYKFAISLCT
    61  SYLCVSFLKT IFPSQNGHDG STDVQQRARR SNCRRQEGIK IVLEDIFTLW RQVETKVRAK
   121  IRKMKVTTKV NRHDKINGKR KTAKEHLRKL SMKEREHGEK ERQVSEAEEN GKLDMKEIHT
   181  YMEMFQRAQA LRRRAEDYYR CKITPSARKP LCNRVRMAAV EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSIIDNS LSLKTPSECV LYPLPPSADD NLKTPPECLL TPLPPSALPS
   301  ADDNLKTPAE CLLYPLPPSA DDNLKTPPEC LLTPLPPSAP PSADDNLKTP PECVCSLPFH
   361  PQRMIISRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPA6 as an antibody target. Whether an autoantibody or antibody against NPIPA6 could matter depends on whether native NPIPA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPA6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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