Seroatlas · Human Serome Atlas

NPIPA5

Nuclear pore complex-interacting protein family member A5

Also known as: NPIA5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
E9PKD4
Gene
NPIPA5
Ensembl
ENSG00000183793
Chromosome
16
Canonical length
350 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for NPIPA5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>E9PKD4|NPIPA5
     1  MFCCLGYEWL SGGCKTWHSA WVINTLADHR HRGTDFGGSP WLLIITVFLR SYKFAISLCT
    61  SYLCVSFLKT IFPSQNGHDG STDVQQRARR SNCRRQEGIK IVLEDIFTLW RQVETKVRAK
   121  IRKMKVTTKV NRHDKINGKR KTAKEHLRKL SMKEREHGEK ERQVSEAEEN GKLDMKEIHT
   181  YMEMFQRAQA LRRRAEDYYR CKITPSARKP LCNRVRMAAV EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSIIDNS LSLKTPSERL LYPLPPSADD NLKTPPECLL TPLPPSALPS
   301  ADDNLKTPAE CLLTPLPPSA PPSADDNLKT PPECVCSLPF HPQRMIISRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
160 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 160 nTPM
  • pituitary gland: 74 nTPM
  • cerebral cortex: 55 nTPM
  • hippocampal formation: 48 nTPM
  • hypothalamus: 44 nTPM
  • ovary: 42 nTPM

Single-cell type

  • distal convoluted tubule cells: 2.7 nCPM
  • loop of henle epithelial cells: 2.4 nCPM
  • proximal tubule cells: 2.4 nCPM
  • papillary tip epithelial cells: 2.2 nCPM
  • renal connecting tubule cells: 2.2 nCPM
  • renal collecting duct principal cells: 2.1 nCPM

Immune cell

  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 23 nTPM
  • cerebral cortex: 17 nTPM
  • hypothalamus: 15 nTPM
  • medulla oblongata: 14 nTPM
  • pons: 14 nTPM
  • midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.86
gnomAD pLI
0.11
gnomAD missense Z
-1.95

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPA5 as an antibody target. Whether an autoantibody or antibody against NPIPA5 could matter depends on whether native NPIPA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPIPA5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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