Seroatlas · Human Serome Atlas

NPIPA3

Nuclear pore complex-interacting protein family member A3

Also known as: NPIA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
F8WFD2
Gene
NPIPA3
Ensembl
ENSG00000224712
Chromosome
16
Canonical length
350 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in mRNA transport and protein transport. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>F8WFD2|NPIPA3
     1  MFCCLGYEWL SGGCKTWHSA WVINTLADHR HRGTDFGGSP WLLIITVFLR SYKFAISLCT
    61  SYLCVSFLKT IFPSQNGHDG STDVQQRARR SNRRRQEGIK IVLEDIFTLW RQVETKVRAK
   121  ICKMKVTTKV NRHDKINGKR KTAKEHLRKL SMKEREHGEK ERQVSEAEEN GKLDMKEIHT
   181  YMEMFQRAQA LRRRAEDYYR CKITPSARKP LCNRVRMAAA EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSIIDNS LSLKTPPECL LTPLPPSALP SADDNLKTPA ECLLYPLPPS
   301  ADDNLKTPPE CLLTPLPPSA PPSVDDNLKT PPKCVCSLPF HPQRMIISRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 25 nTPM
  • pituitary gland: 10 nTPM
  • colon: 8.7 nTPM
  • blood vessel: 7.9 nTPM
  • cerebral cortex: 7.5 nTPM
  • ovary: 7.4 nTPM

Single-cell type

  • mucous neck cells: 0.8 nCPM
  • papillary tip epithelial cells: 0.4 nCPM
  • loop of henle epithelial cells: 0.2 nCPM
  • proximal tubule cells: 0.2 nCPM
  • renal collecting duct intercalated cells: 0.2 nCPM
  • renal connecting tubule cells: 0.2 nCPM

Immune cell

  • memory B-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 8.9 nTPM
  • pons: 6.6 nTPM
  • cerebral cortex: 6.3 nTPM
  • white matter: 6.1 nTPM
  • medulla oblongata: 6 nTPM
  • midbrain: 5.5 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPA3 as an antibody target. Whether an autoantibody or antibody against NPIPA3 could matter depends on whether native NPIPA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPIPA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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