Seroatlas · Human Serome Atlas

NPIPA2

Nuclear pore complex-interacting protein family member A2

Also known as: NPIA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
E9PIF3
Gene
NPIPA2
Ensembl
ENSG00000254852
Chromosome
16
Canonical length
369 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in mRNA transport and protein transport. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>E9PIF3|NPIPA2
     1  MVKLSIVLTP RFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHRH RGTDFGGSPW
    61  LLIITVFLRS YKFAISLCTS YLCVSFLKTI FPSQNGHDGS TDVQQRARRS NRRRQEGIKI
   121  VLEDIFTLWR QVETKVRAKI CKMKVTTKVN RHDKINGKRK TAKEHLRKLS MKEREHGEKE
   181  RQVSEAEENG KLDMKEIHTY MEMFQRAQAL RRRAEDYYRC KITPSARKPL CNRVRMAAAE
   241  HRHSSGLPYW PYLTAETLKN RMGHQPPPPT QQHSIIDNSL SLKTPPECLL TPLPPSALPS
   301  ADDNLKTPAE CLLYPLPPSA DDNLKTPPEC LLTPLPPSAP PSADDNLKTP PKCVCSLPFH
   361  PQRMIISRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 22 nTPM
  • testis: 14 nTPM
  • pituitary gland: 8.9 nTPM
  • colon: 8.4 nTPM
  • blood vessel: 7.9 nTPM
  • skeletal muscle: 6.6 nTPM

Single-cell type

  • podocytes: 1 nCPM
  • early spermatids: 0.7 nCPM
  • late primary spermatocytes: 0.7 nCPM
  • renal collecting duct intercalated cells: 0.5 nCPM
  • distal convoluted tubule cells: 0.4 nCPM
  • astrocytes: 0.3 nCPM

Immune cell

  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 8.5 nTPM
  • cerebral cortex: 6.4 nTPM
  • pons: 5.3 nTPM
  • white matter: 5.3 nTPM
  • medulla oblongata: 4.7 nTPM
  • hippocampal formation: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.02

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPA2 as an antibody target. Whether an autoantibody or antibody against NPIPA2 could matter depends on whether native NPIPA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPIPA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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