Seroatlas · Human Serome Atlas

NPIPA1

Nuclear pore complex-interacting protein family member A1

Also known as: morpheus, NPIA1_HUMAN, NPIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UND3
Gene: NPIPA1
Ensembl: ENSG00000183426
Chromosome: 16
Canonical length: 350 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in mRNA transport and protein transport. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q9UND3|NPIPA1
     1  MFCCLGYEWL SGGCKTWHSA WVINTLADHR HRGTDFGGSP WLLIITVFLR SYKFAISLCT
    61  SYLCVSFLKT IFPSQNGHDG STDVQQRARR SNRRRQEGIK IVLEDIFTLW RQVETKVRAK
   121  IRKMKVTTKV NRHDKINGKR KTAKEHLRKL SMKEREHGEK ERQVSEAEEN GKLDMKEIHT
   181  YMEMFQRAQA LRRRAEDYYR CKITPSARKP LCNRVRMAAV EHRHSSGLPY WPYLTAETLK
   241  NRMGHQPPPP TQQHSIIDNS LSLKTPSECL LTPLPPSALP SADDNLKTPA ECLLYPLPPS
   301  ADDNLKTPPE CLLTPLPPSA PPSVDDNLKT PPECVCSLPF HPQRMIISRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPIPA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 352 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 352 nTPM
pituitary gland: 155 nTPM
cerebral cortex: 115 nTPM
ovary: 100 nTPM
hippocampal formation: 96 nTPM
testis: 93 nTPM

Single-cell type

early spermatids: 47 nCPM
brain excitatory neurons: 45 nCPM
ependymal cells: 44 nCPM
astrocytes: 35 nCPM
oligodendrocyte progenitor cells: 33 nCPM
bergmann glia: 32 nCPM

Immune cell

memory B-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
basophil: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebellum: 62 nTPM
cerebral cortex: 44 nTPM
hippocampal formation: 33 nTPM
amygdala: 32 nTPM
pons: 31 nTPM
medulla oblongata: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0.32
gnomAD missense Z: -0.66

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPIPA1 as an antibody target. Whether an autoantibody or antibody against NPIPA1 could matter depends on whether native NPIPA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPIPA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPIPA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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